|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2003-4-8
|
|
pubmed:abstractText |
The synthesis of tetra(hexa)hydropyrazolo[1,2-a]pyrido[3,4-d]pyridazine derivatives (14-21) and the results of pharmacological screening are described in this paper. All compounds tested were non-toxic and showed a significant analgesic action. The analgesic effects were associated with the suppression of the spontaneous locomotor activity. Furthermore most of the synthesized compounds displayed a weak antimycobacterial action in the preliminary screening.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0006-6648
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
142
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
21-7
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:12680035-Analgesics, Non-Narcotic,
pubmed-meshheading:12680035-Animals,
pubmed-meshheading:12680035-Anti-Bacterial Agents,
pubmed-meshheading:12680035-Blood Pressure,
pubmed-meshheading:12680035-Lethal Dose 50,
pubmed-meshheading:12680035-Mice,
pubmed-meshheading:12680035-Microbial Sensitivity Tests,
pubmed-meshheading:12680035-Motor Activity,
pubmed-meshheading:12680035-Mycobacterium,
pubmed-meshheading:12680035-Pain Measurement,
pubmed-meshheading:12680035-Pyrazoles,
pubmed-meshheading:12680035-Pyridazines,
pubmed-meshheading:12680035-Rats,
pubmed-meshheading:12680035-Rats, Wistar
|
|
pubmed:articleTitle |
Synthesis and properties of tetra(hexa)hydropyrazolo [1,2-a]pyrido[3,4-d]pyridazine derivatives.
|
|
pubmed:affiliation |
Department of Chemistry of Drugs, Wroc?aw University of Medicine, Wroc?aw, Poland.
|
|
pubmed:publicationType |
Journal Article
|
