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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-4-25
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pubmed:abstractText |
GABA(A) receptors can mediate both 'phasic' synaptic inhibition and a persistent 'tonic' form of signaling. We show that, in the presence of intact GABA uptake, guinea pig hippocampal interneurons, but not pyramidal cells, express a tonic GABA(A) receptor-mediated conductance. This conductance was pharmacologically distinct from spontaneous inhibitory postsynaptic currents (IPSCs). Inhibiting GABA uptake resulted in the expression of a comparable GABA(A) receptor-mediated tonic conductance in pyramidal cells. Reducing the tonic conductance in interneurons enhanced their excitability and the inhibitory drive to pyramidal cells. These results point to a role for cell type-dependent tonic inhibition in regulating cortical excitability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1097-6256
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
484-90
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12679782-Animals,
pubmed-meshheading:12679782-GABA Antagonists,
pubmed-meshheading:12679782-GABA-A Receptor Agonists,
pubmed-meshheading:12679782-GABA-A Receptor Antagonists,
pubmed-meshheading:12679782-Guinea Pigs,
pubmed-meshheading:12679782-Hippocampus,
pubmed-meshheading:12679782-Interneurons,
pubmed-meshheading:12679782-Neural Inhibition,
pubmed-meshheading:12679782-Pyramidal Cells,
pubmed-meshheading:12679782-Receptors, GABA-A,
pubmed-meshheading:12679782-Synaptic Transmission,
pubmed-meshheading:12679782-gamma-Aminobutyric Acid
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pubmed:year |
2003
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pubmed:articleTitle |
GABA uptake regulates cortical excitability via cell type-specific tonic inhibition.
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pubmed:affiliation |
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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