12679263

Source:http://linkedlifedata.com/resource/pubmed/id/12679263

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0012634, umls-concept:C0013546, umls-concept:C0021149, umls-concept:C0456103, umls-concept:C0456337, umls-concept:C1136254, umls-concept:C1280500, umls-concept:C1708528, umls-concept:C1833334
pubmed:issue	4
pubmed:dateCreated	2003-4-7
pubmed:abstractText	Sepsis occurring in the first week of life can be a devastating neonatal problem. Group B streptococci (GBS) and enterobacteriaceae are the main causes of early-onset sepsis in more developed countries. Intrapartum antimicrobial prophylaxis (IAP) has lowered the incidence of early-onset GBS sepsis by 50-80%. However, there are concerns that the use of IAP may select for infections caused by enterobacteriaceae, including some strains resistant to antimicrobials. We explored potential associations between IAP use and changes in the causes of early-onset sepsis. We concluded that there have been substantial declines in the incidence of early-onset infections due to GBS and, in some settings, other bacteria. Increases in the frequencies of non-GBS or antimicrobial-resistant early-onset sepsis have been limited to preterm, low-birthweight, or very-low-birthweight neonates. We propose systematic monitoring of early-onset sepsis, coupled with targeted research, to inform periodic reassessment of prevention strategies.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101130150
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	1473-3099
pubmed:author	pubmed-author:MooreMatthew RMR, pubmed-author:SchragStephanie JSJ, pubmed-author:SchuchatAnneA
pubmed:issnType	Print
pubmed:volume	3
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	201-13
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:12679263-Antibiotic Prophylaxis, pubmed-meshheading:12679263-Clinical Trials as Topic, pubmed-meshheading:12679263-Female, pubmed-meshheading:12679263-Humans, pubmed-meshheading:12679263-Incidence, pubmed-meshheading:12679263-Infant, Newborn, pubmed-meshheading:12679263-Multicenter Studies as Topic, pubmed-meshheading:12679263-Pregnancy, pubmed-meshheading:12679263-Sepsis, pubmed-meshheading:12679263-Streptococcal Infections, pubmed-meshheading:12679263-Streptococcus agalactiae
pubmed:year	2003
pubmed:articleTitle	Effects of intrapartum antimicrobial prophylaxis for prevention of group-B-streptococcal disease on the incidence and ecology of early-onset neonatal sepsis.
pubmed:affiliation	Epidemic Intelligence Service Program, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA, USA. mmoore4@cdc.gov
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Review