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rdf:type |
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lifeskim:mentions |
umls-concept:C0007028,
umls-concept:C0015392,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0017601,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0699040,
umls-concept:C1167322,
umls-concept:C1413041,
umls-concept:C1413052,
umls-concept:C1514559,
umls-concept:C2752508,
umls-concept:C2911684
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pubmed:issue |
4
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pubmed:dateCreated |
2003-4-4
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pubmed:abstractText |
Carbonic anhydrase enzymes (CAs) are universally involved in many fundamental physiological processes, including acid base regulation and fluid formation and movement. In glaucoma patients, CA inhibitors are very effective in lowering intraocular pressure by reducing the rate of aqueous humour secretion mediated by the CAs in the ciliary epithelium. In this work, we investigated the expression and tissue distribution of two recently discovered CA genes CA9 (CAIX) and CA12 (CAXII) in fetal, neonatal, and adult human eyes with and without glaucoma.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-11224713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-11231628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-11238039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-11506497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-11834836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-11880716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-11890262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-13114318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-2307193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-2553750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-7574487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-8084592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-8661007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-8795459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-9005853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-9516235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-9636197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12676895-9770531
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1468-6244
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
257-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12676895-Blotting, Northern,
pubmed-meshheading:12676895-Carbonic Anhydrases,
pubmed-meshheading:12676895-Cell Membrane,
pubmed-meshheading:12676895-Cells, Cultured,
pubmed-meshheading:12676895-Ciliary Body,
pubmed-meshheading:12676895-Epithelial Cells,
pubmed-meshheading:12676895-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:12676895-Glaucoma,
pubmed-meshheading:12676895-Humans,
pubmed-meshheading:12676895-Immunohistochemistry,
pubmed-meshheading:12676895-Isoenzymes,
pubmed-meshheading:12676895-RNA, Messenger
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pubmed:year |
2003
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pubmed:articleTitle |
Expression of cell surface transmembrane carbonic anhydrase genes CA9 and CA12 in the human eye: overexpression of CA12 (CAXII) in glaucoma.
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pubmed:affiliation |
Department of Microbiology and Molecular Genetics, College of Medicine, University of California at Irvine, 92697-4025, USA. syliao@uci.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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