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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-4-4
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pubmed:abstractText |
Wnt genes play important roles in regulating patterning and morphogenesis during vertebrate gastrulation. In zebrafish, slb/wnt11 is required for convergence and extension movements, but not cell fate specification during gastrulation. To determine if other Wnt genes functionally interact with slb/wnt11, we analysed the role of ppt/wnt5 during zebrafish gastrulation. ppt/wnt5 is maternally provided and zygotically expressed at all stages during gastrulation. The analysis of ppt mutant embryos reveals that Ppt/Wnt5 regulates cell elongation and convergent extension movements in posterior regions of the gastrula, while its function in more anterior regions is largely redundant to that of Slb/Wnt11. Frizzled-2 functions downstream of ppt/wnt5, indicating that it might act as a receptor for Ppt/Wnt5 in this process. The characterisation of the role of Ppt/Wnt5 provides insight into the functional diversity of Wnt genes in regulating vertebrate gastrulation movements.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt11 protein, zebrafish,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0925-4773
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
120
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
467-76
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12676324-Animals,
pubmed-meshheading:12676324-Cell Lineage,
pubmed-meshheading:12676324-Gastrula,
pubmed-meshheading:12676324-Gene Expression Regulation, Developmental,
pubmed-meshheading:12676324-Glycoproteins,
pubmed-meshheading:12676324-In Situ Hybridization,
pubmed-meshheading:12676324-Microscopy, Confocal,
pubmed-meshheading:12676324-Mutation,
pubmed-meshheading:12676324-Oligonucleotides, Antisense,
pubmed-meshheading:12676324-Phenotype,
pubmed-meshheading:12676324-Proto-Oncogene Proteins,
pubmed-meshheading:12676324-Receptors, Neurotransmitter,
pubmed-meshheading:12676324-Signal Transduction,
pubmed-meshheading:12676324-Time Factors,
pubmed-meshheading:12676324-Transcription Factors,
pubmed-meshheading:12676324-Wnt Proteins,
pubmed-meshheading:12676324-Zebrafish,
pubmed-meshheading:12676324-Zebrafish Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation.
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pubmed:affiliation |
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerasse 108, 01307 Dresden, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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