| pubmed-article:12676256 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12676256 | lifeskim:mentions | umls-concept:C0029172 | lld:lifeskim |
| pubmed-article:12676256 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:12676256 | lifeskim:mentions | umls-concept:C1418252 | lld:lifeskim |
| pubmed-article:12676256 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12676256 | pubmed:dateCreated | 2003-4-4 | lld:pubmed |
| pubmed-article:12676256 | pubmed:abstractText | Type I plasminogen activator inhibitor (PAI-1) is a 50 kDa glycoprotein belonging to the serine protease superfamily. PAI-1 is consistently and dramatically upregulated in a variety of fibrotic diseases. The aim of this study was to compare PAI-1 expression in normal human buccal mucosa and oral submucous fibrosis (OSF) specimens and further explore the potential mechanism that may lead to induced PAI-1 expression. Twenty-five OSF specimens and six normal buccal mucosa were examined by immunohistochemistry. The activity of PAI-1 from cells cultured from OSF and normal buccal mucosa were assayed using reverse-transcriptase polymerase chain reaction (RT-PCR) and Western blots. PAI-1 expression was significantly higher in OSF specimens and expressed mainly by fibroblasts, endothelial cells, and inflammatory cells. In addition, OSF exhibited higher PAI-1 expression than normal buccal mucosa fibroblast (BMF) both in mRNA and protein levels. To verify whether arecoline, a major areca nut alkaloid, could affect PAI-1 expression by human BMFs, RT-PCR and Western blots were used. The results demonstrated highly elevated PAI-1 mRNA and protein expression in normal human BMFs stimulated by arecoline. Taken together, these results suggest that PAI-1 expression is significantly upregulated in OSF tissues from areca quid chewers, and arecoline may be responsible for the enhanced PAI-1 expression in vivo. | lld:pubmed |
| pubmed-article:12676256 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12676256 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12676256 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12676256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12676256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12676256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12676256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12676256 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12676256 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12676256 | pubmed:issn | 1368-8375 | lld:pubmed |
| pubmed-article:12676256 | pubmed:author | pubmed-author:ChangYu-ChaoY... | lld:pubmed |
| pubmed-article:12676256 | pubmed:author | pubmed-author:HsiehYih-Shou... | lld:pubmed |
| pubmed-article:12676256 | pubmed:author | pubmed-author:ChouMing-Yung... | lld:pubmed |
| pubmed-article:12676256 | pubmed:author | pubmed-author:TsaiChung-Hun... | lld:pubmed |
| pubmed-article:12676256 | pubmed:author | pubmed-author:YangShun-FaSF | lld:pubmed |
| pubmed-article:12676256 | pubmed:copyrightInfo | Copyright 2003 Elsevier Science Ltd. | lld:pubmed |
| pubmed-article:12676256 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12676256 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:12676256 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12676256 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12676256 | pubmed:pagination | 367-72 | lld:pubmed |
| pubmed-article:12676256 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12676256 | pubmed:meshHeading | pubmed-meshheading:12676256... | lld:pubmed |
| pubmed-article:12676256 | pubmed:meshHeading | pubmed-meshheading:12676256... | lld:pubmed |
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| pubmed-article:12676256 | pubmed:meshHeading | pubmed-meshheading:12676256... | lld:pubmed |
| pubmed-article:12676256 | pubmed:meshHeading | pubmed-meshheading:12676256... | lld:pubmed |
| pubmed-article:12676256 | pubmed:meshHeading | pubmed-meshheading:12676256... | lld:pubmed |
| pubmed-article:12676256 | pubmed:meshHeading | pubmed-meshheading:12676256... | lld:pubmed |
| pubmed-article:12676256 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12676256 | pubmed:articleTitle | The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis. | lld:pubmed |
| pubmed-article:12676256 | pubmed:affiliation | Institute of Biochemistry, Chung Shan Medical University, Taichung, Taiwan. | lld:pubmed |
| pubmed-article:12676256 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12676256 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
