12673842

Source:http://linkedlifedata.com/resource/pubmed/id/12673842

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0002895, umls-concept:C0011175, umls-concept:C0014792, umls-concept:C0087111, umls-concept:C1708528
pubmed:issue	1
pubmed:dateCreated	2003-4-3
pubmed:abstractText	One of the pathogenetic mechanisms responsible for sickling of erythrocytes in patients with sickle cell disease is the decreased hydration status of the cells. In this brief review, we discuss the pathophysiologic background and explore some new treatment options to prevent vaso-occlusive crises or other problems in this patient population.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100885435
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Clotrimazole, http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin, Sickle, http://linkedlifedata.com/resource/pubmed/chemical/Magnesium, http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels..., http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Potassium-Exchanging ATPase, http://linkedlifedata.com/resource/pubmed/chemical/Symporters, http://linkedlifedata.com/resource/pubmed/chemical/potassium-chloride symporters
pubmed:status	MEDLINE
pubmed:issn	1522-7952
pubmed:author	pubmed-author:BrugnaraCC, pubmed-author:MuellerB UBU
pubmed:issnType	Print
pubmed:volume	20
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	15-25
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:12673842-Adult, pubmed-meshheading:12673842-Anemia, Sickle Cell, pubmed-meshheading:12673842-Animals, pubmed-meshheading:12673842-Body Water, pubmed-meshheading:12673842-Child, pubmed-meshheading:12673842-Clotrimazole, pubmed-meshheading:12673842-Dehydration, pubmed-meshheading:12673842-Disease Models, Animal, pubmed-meshheading:12673842-Erythrocytes, Abnormal, pubmed-meshheading:12673842-Hemoglobin, Sickle, pubmed-meshheading:12673842-Humans, pubmed-meshheading:12673842-Ion Transport, pubmed-meshheading:12673842-Magnesium, pubmed-meshheading:12673842-Mice, pubmed-meshheading:12673842-Mice, Transgenic, pubmed-meshheading:12673842-Oxidative Stress, pubmed-meshheading:12673842-Potassium Channels, Calcium-Activated, pubmed-meshheading:12673842-Sodium-Potassium-Exchanging ATPase, pubmed-meshheading:12673842-Solubility, pubmed-meshheading:12673842-Symporters
pubmed:articleTitle	Prevention of red cell dehydration: a possible new treatment for sickle cell disease.
pubmed:affiliation	Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. mueller_b@al.tch.harvard.edu
pubmed:publicationType	Journal Article, Review