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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-4-3
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pubmed:abstractText |
In eukaryotes, mRNAs are monitored for errors in gene expression by RNA surveillance where untranslatable mRNAs are selectively degraded by the nonsense-mediated mRNA decay (NMD) pathway. Depending on the organism, three to seven genes are required for NMD. Besides RNA surveillance, the genes required for NMD serve a second purpose by controlling the overall abundance of a substantial fraction of the transcriptome.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0959-437X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
207-14
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12672499-Animals,
pubmed-meshheading:12672499-Evolution, Molecular,
pubmed-meshheading:12672499-Humans,
pubmed-meshheading:12672499-Phylogeny,
pubmed-meshheading:12672499-RNA, Messenger,
pubmed-meshheading:12672499-RNA Helicases,
pubmed-meshheading:12672499-Saccharomyces cerevisiae,
pubmed-meshheading:12672499-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:12672499-Sequence Alignment,
pubmed-meshheading:12672499-Sequence Analysis, Protein,
pubmed-meshheading:12672499-Trans-Activators
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pubmed:year |
2003
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pubmed:articleTitle |
Looking at mRNA decay pathways through the window of molecular evolution.
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pubmed:affiliation |
Robert M Bock Laboratories, 1525 Linden Drive, University of Wisconsin, Madison, Wisconsin 53706, USA. mrculber@facstaff.wisc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
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