|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007158,
umls-concept:C0017977,
umls-concept:C0032521,
umls-concept:C0205099,
umls-concept:C0331858,
umls-concept:C0332624,
umls-concept:C0868939,
umls-concept:C1261381,
umls-concept:C1334956,
umls-concept:C1704640,
umls-concept:C1706515,
umls-concept:C1883254
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2003-4-3
|
|
pubmed:abstractText |
An octyl N-acetylglucosaminide derivative with a pentaerythritol chain at position 6 has been synthesized and evaluated as an inhibitor of neural tumor growth. The glycoside inhibited the growth of a neuroectodermic tumor implanted in rats and, when loaded on a slow-delivery polymer disk, caused the destruction of cultured human astroblastoma obtained after surgical biopsy.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0022-2623
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:day |
10
|
|
pubmed:volume |
46
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1286-8
|
|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:12672228-Acetylglucosamine,
pubmed-meshheading:12672228-Animals,
pubmed-meshheading:12672228-Antineoplastic Agents,
pubmed-meshheading:12672228-Brain Neoplasms,
pubmed-meshheading:12672228-Delayed-Action Preparations,
pubmed-meshheading:12672228-Drug Carriers,
pubmed-meshheading:12672228-Female,
pubmed-meshheading:12672228-Glycosides,
pubmed-meshheading:12672228-Humans,
pubmed-meshheading:12672228-Male,
pubmed-meshheading:12672228-Neoplasm Transplantation,
pubmed-meshheading:12672228-Neoplasms, Neuroepithelial,
pubmed-meshheading:12672228-Neuroectodermal Tumors, Primitive,
pubmed-meshheading:12672228-Polymers,
pubmed-meshheading:12672228-Propylene Glycols,
pubmed-meshheading:12672228-Rats,
pubmed-meshheading:12672228-Rats, Wistar,
pubmed-meshheading:12672228-Tumor Cells, Cultured
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|
pubmed:year |
2003
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|
pubmed:articleTitle |
Central neural tumor destruction by controlled release of a synthetic glycoside dispersed in a biodegradable polymeric matrix.
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|
pubmed:affiliation |
Instituto de Química Orgánica General, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain. iqofm68@iqog.csic.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
