| pubmed-article:12670506 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12670506 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:12670506 | lifeskim:mentions | umls-concept:C0016057 | lld:lifeskim |
| pubmed-article:12670506 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:12670506 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:12670506 | lifeskim:mentions | umls-concept:C0056695 | lld:lifeskim |
| pubmed-article:12670506 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:12670506 | lifeskim:mentions | umls-concept:C1366765 | lld:lifeskim |
| pubmed-article:12670506 | lifeskim:mentions | umls-concept:C0220802 | lld:lifeskim |
| pubmed-article:12670506 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:12670506 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:12670506 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:12670506 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:12670506 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12670506 | pubmed:dateCreated | 2003-4-2 | lld:pubmed |
| pubmed-article:12670506 | pubmed:abstractText | We evaluated the role of MAPKs on apoptosis induced by butyrate in cells derived from a human fibrosarcoma (2C4). Culture of 2C4 cells in 5% of fetal bovine serum (FBS) induced ERK1/2 and CREB phosphorylation and delayed apoptosis induced by butyrate. Butyrate inhibited phosphorylation of ERK1/2 and CREB. Furthermore, the use of specific inhibitors PD98059 (MEK) and H89 (PKA), which block ERK1/2 and CREB phosphorylation, accelerated butyrate induced cell death in 2C4 cells. The butyrate effect was shown to be dependent on caspase activation, once caspase inhibitors restored phosphorylation of ERK1/2 and CREB in 2C4 cells. However, the proteolytic effect of caspases was not directly on ERK1/2 and CREB proteins. In conclusion, butyrate induced apoptosis in 2C4 cells is regulated by the levels of ERK1/2 and CREB phosphorylation in a caspase dependent mechanism. | lld:pubmed |
| pubmed-article:12670506 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12670506 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670506 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12670506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670506 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12670506 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12670506 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:12670506 | pubmed:author | pubmed-author:BonjardimCláu... | lld:pubmed |
| pubmed-article:12670506 | pubmed:author | pubmed-author:Alvarez-Leite... | lld:pubmed |
| pubmed-article:12670506 | pubmed:author | pubmed-author:GazzinelliRic... | lld:pubmed |
| pubmed-article:12670506 | pubmed:author | pubmed-author:RopertCatheri... | lld:pubmed |
| pubmed-article:12670506 | pubmed:author | pubmed-author:RabeloFlávia... | lld:pubmed |
| pubmed-article:12670506 | pubmed:author | pubmed-author:RamosMariana... | lld:pubmed |
| pubmed-article:12670506 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12670506 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:12670506 | pubmed:volume | 303 | lld:pubmed |
| pubmed-article:12670506 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12670506 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12670506 | pubmed:pagination | 968-72 | lld:pubmed |
| pubmed-article:12670506 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:12670506 | pubmed:meshHeading | pubmed-meshheading:12670506... | lld:pubmed |
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| pubmed-article:12670506 | pubmed:meshHeading | pubmed-meshheading:12670506... | lld:pubmed |
| pubmed-article:12670506 | pubmed:meshHeading | pubmed-meshheading:12670506... | lld:pubmed |
| pubmed-article:12670506 | pubmed:meshHeading | pubmed-meshheading:12670506... | lld:pubmed |
| pubmed-article:12670506 | pubmed:meshHeading | pubmed-meshheading:12670506... | lld:pubmed |
| pubmed-article:12670506 | pubmed:meshHeading | pubmed-meshheading:12670506... | lld:pubmed |
| pubmed-article:12670506 | pubmed:meshHeading | pubmed-meshheading:12670506... | lld:pubmed |
| pubmed-article:12670506 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12670506 | pubmed:articleTitle | Inhibition of ERK1/2 and CREB phosphorylation by caspase-dependent mechanism enhances apoptosis in a fibrosarcoma cell line treated with butyrate. | lld:pubmed |
| pubmed-article:12670506 | pubmed:affiliation | Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Caixa Postal 486, CEP 30 161-970, Belo Horizonte, Minas Gerais, Brazil. | lld:pubmed |
| pubmed-article:12670506 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12670506 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
