| pubmed-article:12670505 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12670505 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12670505 | lifeskim:mentions | umls-concept:C0078058 | lld:lifeskim |
| pubmed-article:12670505 | lifeskim:mentions | umls-concept:C2330894 | lld:lifeskim |
| pubmed-article:12670505 | lifeskim:mentions | umls-concept:C0378516 | lld:lifeskim |
| pubmed-article:12670505 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12670505 | lifeskim:mentions | umls-concept:C0213321 | lld:lifeskim |
| pubmed-article:12670505 | lifeskim:mentions | umls-concept:C1171892 | lld:lifeskim |
| pubmed-article:12670505 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12670505 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12670505 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12670505 | pubmed:dateCreated | 2003-4-2 | lld:pubmed |
| pubmed-article:12670505 | pubmed:abstractText | We previously demonstrated that differentiated retinal pigment epithelial (RPE) cells express high levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF), and a critical balance between VEGF and PEDF is important to prevent the development of choroidal neovascularization. We report here that VEGF secreted by RPE cells upregulates PEDF expression via VEGFR-1 in an autocrine manner. PEDF mRNA and protein expression was downregulated by neutralizing antibody against VEGF in differentiated human RPE cells. VEGFR-1 neutralization decreased PEDF mRNA and protein expression whereas anti-VEGFR-2 antibody had no effect. Addition of placenta growth factor (PlGF) restored PEDF expression in the presence of anti-VEGF antibody. These results demonstrate a regulatory interaction between angiogenesis stimulators and inhibitors to maintain homeostasis in normal human retina. | lld:pubmed |
| pubmed-article:12670505 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12670505 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670505 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12670505 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12670505 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670505 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12670505 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12670505 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:12670505 | pubmed:author | pubmed-author:MoritaIkuoI | lld:pubmed |
| pubmed-article:12670505 | pubmed:author | pubmed-author:MochizukiMana... | lld:pubmed |
| pubmed-article:12670505 | pubmed:author | pubmed-author:Ohno-MatsuiKy... | lld:pubmed |
| pubmed-article:12670505 | pubmed:author | pubmed-author:YoshidaTakesh... | lld:pubmed |
| pubmed-article:12670505 | pubmed:author | pubmed-author:UetamaTomokoT | lld:pubmed |
| pubmed-article:12670505 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12670505 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:12670505 | pubmed:volume | 303 | lld:pubmed |
| pubmed-article:12670505 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12670505 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12670505 | pubmed:pagination | 962-7 | lld:pubmed |
| pubmed-article:12670505 | pubmed:dateRevised | 2009-11-25 | lld:pubmed |
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| pubmed-article:12670505 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12670505 | pubmed:articleTitle | Vascular endothelial growth factor upregulates pigment epithelium-derived factor expression via VEGFR-1 in human retinal pigment epithelial cells. | lld:pubmed |
| pubmed-article:12670505 | pubmed:affiliation | Department of Ophthalmology and Visual Science, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. k.ohno.oph@tmd.ac.jp | lld:pubmed |
| pubmed-article:12670505 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12670505 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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