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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-4-2
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pubmed:abstractText |
We previously demonstrated that differentiated retinal pigment epithelial (RPE) cells express high levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF), and a critical balance between VEGF and PEDF is important to prevent the development of choroidal neovascularization. We report here that VEGF secreted by RPE cells upregulates PEDF expression via VEGFR-1 in an autocrine manner. PEDF mRNA and protein expression was downregulated by neutralizing antibody against VEGF in differentiated human RPE cells. VEGFR-1 neutralization decreased PEDF mRNA and protein expression whereas anti-VEGFR-2 antibody had no effect. Addition of placenta growth factor (PlGF) restored PEDF expression in the presence of anti-VEGF antibody. These results demonstrate a regulatory interaction between angiogenesis stimulators and inhibitors to maintain homeostasis in normal human retina.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Pregnancy Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Serpins,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/pigment epithelium-derived factor,
http://linkedlifedata.com/resource/pubmed/chemical/placenta growth factor
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
303
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
962-7
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pubmed:dateRevised |
2009-11-25
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pubmed:meshHeading |
pubmed-meshheading:12670505-Cells, Cultured,
pubmed-meshheading:12670505-Endothelial Growth Factors,
pubmed-meshheading:12670505-Eye Proteins,
pubmed-meshheading:12670505-Feedback,
pubmed-meshheading:12670505-Gene Expression,
pubmed-meshheading:12670505-Humans,
pubmed-meshheading:12670505-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:12670505-Lymphokines,
pubmed-meshheading:12670505-Neovascularization, Physiologic,
pubmed-meshheading:12670505-Nerve Growth Factors,
pubmed-meshheading:12670505-Pigment Epithelium of Eye,
pubmed-meshheading:12670505-Pregnancy Proteins,
pubmed-meshheading:12670505-Protein Biosynthesis,
pubmed-meshheading:12670505-Proteins,
pubmed-meshheading:12670505-RNA, Messenger,
pubmed-meshheading:12670505-Serpins,
pubmed-meshheading:12670505-Up-Regulation,
pubmed-meshheading:12670505-Vascular Endothelial Growth Factor A,
pubmed-meshheading:12670505-Vascular Endothelial Growth Factor Receptor-1,
pubmed-meshheading:12670505-Vascular Endothelial Growth Factor Receptor-2,
pubmed-meshheading:12670505-Vascular Endothelial Growth Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Vascular endothelial growth factor upregulates pigment epithelium-derived factor expression via VEGFR-1 in human retinal pigment epithelial cells.
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pubmed:affiliation |
Department of Ophthalmology and Visual Science, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. k.ohno.oph@tmd.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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