| pubmed-article:12670494 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12670494 | lifeskim:mentions | umls-concept:C0079281 | lld:lifeskim |
| pubmed-article:12670494 | lifeskim:mentions | umls-concept:C0028928 | lld:lifeskim |
| pubmed-article:12670494 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:12670494 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:12670494 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12670494 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12670494 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12670494 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12670494 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12670494 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12670494 | pubmed:dateCreated | 2003-4-2 | lld:pubmed |
| pubmed-article:12670494 | pubmed:abstractText | This study investigated the effect of oleic acid on the expression levels of endothelin-1 (ET-1) and on the signaling pathways mediating it in human aortic endothelial cells (HAECs). ET-1 mRNA expression was significantly increased by oleic acid in a dose- and time-dependent manner. Elevation of ET-1 expression in response to oleic acid was inhibited by the protein kinase C (PKC) inhibitor, GF109203X, or the NF-kappa B inhibitor, pyrrolidine dithiocarbamate. In addition, both PKC and NF-kappa B activities were significantly increased by oleic acid. Immunoblot analysis revealed that conventional PKCs (PKC-alpha and -beta II isoforms) were significantly increased in the membranous fractions of HAECs treated with oleic acid. PKC inhibitor completely abolished oleic acid-induced NF-kappa B activation, suggesting that PKC activation is upstream of NF-kappa B activation in oleic acid-induced ET-1 expression. These data suggest that elevated plasma oleic acid levels observed in obese, insulin-resistant subjects result in endothelial dysfunction, at least in part, through an increase in ET-1 expression. | lld:pubmed |
| pubmed-article:12670494 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12670494 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670494 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12670494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12670494 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12670494 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12670494 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:12670494 | pubmed:author | pubmed-author:KimYoung MiYM | lld:pubmed |
| pubmed-article:12670494 | pubmed:author | pubmed-author:ParkSeung-Jun... | lld:pubmed |
| pubmed-article:12670494 | pubmed:author | pubmed-author:LeeIn KyuIK | lld:pubmed |
| pubmed-article:12670494 | pubmed:author | pubmed-author:PakYoungmi... | lld:pubmed |
| pubmed-article:12670494 | pubmed:author | pubmed-author:LeeKi-UpKU | lld:pubmed |
| pubmed-article:12670494 | pubmed:author | pubmed-author:ParkJoong-Yeo... | lld:pubmed |
| pubmed-article:12670494 | pubmed:author | pubmed-author:KimMin SeonMS | lld:pubmed |
| pubmed-article:12670494 | pubmed:author | pubmed-author:ParkKi... | lld:pubmed |
| pubmed-article:12670494 | pubmed:author | pubmed-author:KimYun MiYM | lld:pubmed |
| pubmed-article:12670494 | pubmed:author | pubmed-author:SongHai SunHS | lld:pubmed |
| pubmed-article:12670494 | pubmed:author | pubmed-author:LeeJae DamJD | lld:pubmed |
| pubmed-article:12670494 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12670494 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:12670494 | pubmed:volume | 303 | lld:pubmed |
| pubmed-article:12670494 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12670494 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12670494 | pubmed:pagination | 891-5 | lld:pubmed |
| pubmed-article:12670494 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:12670494 | pubmed:meshHeading | pubmed-meshheading:12670494... | lld:pubmed |
| pubmed-article:12670494 | pubmed:meshHeading | pubmed-meshheading:12670494... | lld:pubmed |
| pubmed-article:12670494 | pubmed:meshHeading | pubmed-meshheading:12670494... | lld:pubmed |
| pubmed-article:12670494 | pubmed:meshHeading | pubmed-meshheading:12670494... | lld:pubmed |
| pubmed-article:12670494 | pubmed:meshHeading | pubmed-meshheading:12670494... | lld:pubmed |
| pubmed-article:12670494 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12670494 | pubmed:articleTitle | Oleic acid induces endothelin-1 expression through activation of protein kinase C and NF-kappa B. | lld:pubmed |
| pubmed-article:12670494 | pubmed:affiliation | Department of Internal Medicine, University of Ulsan College of Medicine, Poongnap-dong, Songpa-ku, 138-736, Seoul, South Korea | lld:pubmed |
| pubmed-article:12670494 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12670494 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12670494 | lld:pubmed |
