Source:http://linkedlifedata.com/resource/pubmed/id/12670487
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2003-4-2
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| pubmed:abstractText |
Copines are ubiquitously expressed, phospholipid-binding proteins that have been conserved through evolution. In this paper, we report the cloning and molecular characterization of a new member of the Copine family, Copine 8. This gene has been isolated and characterized using a combination of bioinformatic and experimental approaches. Using an algorithm to cluster ESTs (expressed sequence tags) that are available through the public "GoldenPath" database, Copine 8 was initially identified as a gene predominantly expressed in prostate and testis. Cloning and molecular analysis revealed that this gene is expressed in low-levels in most tissues examined. Two different isoforms of this gene have been isolated. Strongest expression of Copine 8 mRNA is seen in the prostate, heart, and brain. Taken together, this data suggest that Copine 8 may have an important role to play in prostate regulation and development.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0006-291X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
11
|
| pubmed:volume |
303
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
842-7
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12670487-Alternative Splicing,
pubmed-meshheading:12670487-Amino Acid Sequence,
pubmed-meshheading:12670487-Animals,
pubmed-meshheading:12670487-Base Sequence,
pubmed-meshheading:12670487-Carrier Proteins,
pubmed-meshheading:12670487-Cloning, Molecular,
pubmed-meshheading:12670487-DNA, Complementary,
pubmed-meshheading:12670487-Expressed Sequence Tags,
pubmed-meshheading:12670487-Female,
pubmed-meshheading:12670487-Gene Expression,
pubmed-meshheading:12670487-Humans,
pubmed-meshheading:12670487-Male,
pubmed-meshheading:12670487-Molecular Sequence Data,
pubmed-meshheading:12670487-Multigene Family,
pubmed-meshheading:12670487-Pregnancy,
pubmed-meshheading:12670487-Prostate,
pubmed-meshheading:12670487-RNA, Messenger,
pubmed-meshheading:12670487-Rabbits,
pubmed-meshheading:12670487-Sequence Homology, Amino Acid,
pubmed-meshheading:12670487-Testis,
pubmed-meshheading:12670487-Tissue Distribution
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Cloning, molecular characterization, and expression analysis of Copine 8.
|
| pubmed:affiliation |
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive Room 5120 MSC 4262, Bethesda, MD 20892-4264, USA.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|