Source:http://linkedlifedata.com/resource/pubmed/id/12669129
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2003-4-1
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pubmed:abstractText |
Unilateral ureteral obstruction (UUO) is an animal model of accelerated renal tubulointerstitial fibrosis. We have recently shown, using this model, that mice lacking the bradykinin B2-receptor (B2(-/-)) were more susceptible than control animals to the development of tubulointerstitial fibrosis. Angiotensin converting enzyme (ACE) inhibition slows down UUO-induced renal fibrosis. Since ACE-inhibition increases bradykinin and decreases angiotensin II concentrations we have verified if bradykinin is involved in the antifibrotic effects of ACE-inhibition using the UUO-model and B2(-/-) mice. Surprisingly, although ACE-inhibition significantly reduced renal fibrosis, no difference was observed between the degree of tubulointerstitial fibrosis, macrophage infiltration and cell proliferation between ACE-inhibitor treated B2(+/+) and B2(-/-) mice suggesting the absence of a role of the B2-receptor in the antifibrotic effects of ACE-inhibition. This was confirmed at the level of bradykinin-induced activity of enzymes involved in the degradation of the extracellular matrix. However in both mouse strains, ACE-inhibitors were more efficient than AT1 receptor antagonists.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0340-6245
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
735-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12669129-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:12669129-Animals,
pubmed-meshheading:12669129-Cell Division,
pubmed-meshheading:12669129-Collagen,
pubmed-meshheading:12669129-Disease Models, Animal,
pubmed-meshheading:12669129-Extracellular Matrix,
pubmed-meshheading:12669129-Fibrosis,
pubmed-meshheading:12669129-Immunohistochemistry,
pubmed-meshheading:12669129-Kidney,
pubmed-meshheading:12669129-Macrophages,
pubmed-meshheading:12669129-Male,
pubmed-meshheading:12669129-Matrix Metalloproteinase 2,
pubmed-meshheading:12669129-Mice,
pubmed-meshheading:12669129-Mice, Transgenic,
pubmed-meshheading:12669129-Receptor, Bradykinin B2,
pubmed-meshheading:12669129-Time Factors
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pubmed:year |
2003
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pubmed:articleTitle |
The protective effect of angiotensin converting enzyme inhibition in experimental renal fibrosis in mice is not mediated by bradykinin B2 receptor activation.
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pubmed:affiliation |
Inserm U388, Institut Louis Bugnard, CHU Rangueil, 31052 Toulouse, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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