rdf:type |
|
lifeskim:mentions |
umls-concept:C0001942,
umls-concept:C0007107,
umls-concept:C0032529,
umls-concept:C0043157,
umls-concept:C0205349,
umls-concept:C0332281,
umls-concept:C0456387,
umls-concept:C0543414,
umls-concept:C0596244,
umls-concept:C0678478,
umls-concept:C0919534,
umls-concept:C1333715,
umls-concept:C1412236,
umls-concept:C1412237
|
pubmed:issue |
4
|
pubmed:dateCreated |
2003-4-1
|
pubmed:abstractText |
Alcohol and tobacco consumption are recognized risk factors for upper aerodigestive tract tumours, however individual susceptibility to these environmental factors varies. As part of the Rhein-Neckar Larynx-case-control study, this study investigated the potential risk-modifying effect of genetic polymorphisms in enzymes involved in ethanol and tobacco carcinogen metabolism for laryngeal cancer in Germany.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0960-314X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
13
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
225-30
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:12668919-Alcohol Dehydrogenase,
pubmed-meshheading:12668919-Alcohol Drinking,
pubmed-meshheading:12668919-DNA,
pubmed-meshheading:12668919-DNA, Neoplasm,
pubmed-meshheading:12668919-European Continental Ancestry Group,
pubmed-meshheading:12668919-Genotype,
pubmed-meshheading:12668919-Germany,
pubmed-meshheading:12668919-Glutathione Transferase,
pubmed-meshheading:12668919-Humans,
pubmed-meshheading:12668919-Laryngeal Neoplasms,
pubmed-meshheading:12668919-Polymerase Chain Reaction,
pubmed-meshheading:12668919-Polymorphism, Genetic,
pubmed-meshheading:12668919-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:12668919-Smoking
|
pubmed:year |
2003
|
pubmed:articleTitle |
Laryngeal cancer risk in Caucasians is associated with alcohol and tobacco consumption but not modified by genetic polymorphisms in class I alcohol dehydrogenases ADH1B and ADH1C, and glutathione-S-transferases GSTM1 and GSTT1.
|
pubmed:affiliation |
Division of Toxicology and Cancer Risk Factors German Cancer Research Center (DKFZ), Heidelberg, Germany. a.risch@dkfz.de
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|