Linked Life Data

12668005

Source:http://linkedlifedata.com/resource/pubmed/id/12668005

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pubmed-article:12668005pubmed:abstractTextBased on a computational model for 5-HT(1A)R-ligand interaction and QSAR studies, we have designed and synthesized a new series of arylpiperazines 2-8 which exhibit high 5-HT(1A)R affinity and selectivity over alpha(1)-adrenergic receptors. Among them, compound CSP-2503 (4) has been pharmacologically characterized as a 5-HT(1A)R agonist at somatodendritic and postsynaptic sites, endowed with anxiolytic properties.lld:pubmed
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pubmed-article:12668005pubmed:articleTitleDesign and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.lld:pubmed
pubmed-article:12668005pubmed:affiliationDepartamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense, E-28040 Madrid, Spain. mluzir@quim.ucm.eslld:pubmed
pubmed-article:12668005pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12668005pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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