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rdf:type |
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lifeskim:mentions |
umls-concept:C0178819,
umls-concept:C0220781,
umls-concept:C0243192,
umls-concept:C0379900,
umls-concept:C0679083,
umls-concept:C1313500,
umls-concept:C1516769,
umls-concept:C1611588,
umls-concept:C1707689,
umls-concept:C1880157,
umls-concept:C1883254
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pubmed:issue |
8
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pubmed:dateCreated |
2003-4-1
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pubmed:abstractText |
Based on a computational model for 5-HT(1A)R-ligand interaction and QSAR studies, we have designed and synthesized a new series of arylpiperazines 2-8 which exhibit high 5-HT(1A)R affinity and selectivity over alpha(1)-adrenergic receptors. Among them, compound CSP-2503 (4) has been pharmacologically characterized as a 5-HT(1A)R agonist at somatodendritic and postsynaptic sites, endowed with anxiolytic properties.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Anxiety Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzene Derivatives,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:AyalaDavidD,
pubmed-author:BenhamúBellindaB,
pubmed-author:DelgadoMercedesM,
pubmed-author:FernándezEstherE,
pubmed-author:FuentesJosé AJA,
pubmed-author:López-RodríguezMaría LML,
pubmed-author:ManzanaresJorgeJ,
pubmed-author:MorcilloMa JoséMJ,
pubmed-author:OlivellaMireiaM,
pubmed-author:PardoLeonardoL,
pubmed-author:TejadaIgnacioI,
pubmed-author:VisoAlmaA
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1429-32
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12668005-Amino Acid Sequence,
pubmed-meshheading:12668005-Animals,
pubmed-meshheading:12668005-Anti-Anxiety Agents,
pubmed-meshheading:12668005-Benzene Derivatives,
pubmed-meshheading:12668005-Body Temperature,
pubmed-meshheading:12668005-Computer Simulation,
pubmed-meshheading:12668005-Dose-Response Relationship, Drug,
pubmed-meshheading:12668005-Drug Design,
pubmed-meshheading:12668005-HeLa Cells,
pubmed-meshheading:12668005-Humans,
pubmed-meshheading:12668005-Mice,
pubmed-meshheading:12668005-Models, Molecular,
pubmed-meshheading:12668005-Piperazines,
pubmed-meshheading:12668005-Pyrazines,
pubmed-meshheading:12668005-Quantitative Structure-Activity Relationship,
pubmed-meshheading:12668005-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:12668005-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:12668005-Serotonin Receptor Agonists,
pubmed-meshheading:12668005-Synaptic Transmission
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pubmed:year |
2003
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pubmed:articleTitle |
Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.
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pubmed:affiliation |
Departamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense, E-28040 Madrid, Spain. mluzir@quim.ucm.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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