12668004

Source:http://linkedlifedata.com/resource/pubmed/id/12668004

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0031638, umls-concept:C0205460, umls-concept:C0220781, umls-concept:C0441655, umls-concept:C1707689, umls-concept:C1883254
pubmed:issue	8
pubmed:dateCreated	2003-4-1
pubmed:abstractText	The SAR of a series of beta-carboline derived type 5 phosphodiesterase inhibitors has been explored and we have discovered compounds with excellent levels of PDE5 potency and selectivity over PDE6. However, the series exhibits low levels of selectivity over PDE11, a phosphodiesterase with unknown function.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/3',5'-Cyclic-GMP Phosphodiesterases, http://linkedlifedata.com/resource/pubmed/chemical/Benzene Derivatives, http://linkedlifedata.com/resource/pubmed/chemical/Carbolines, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide..., http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/PDE5A protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Diester Hydrolases, http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0960-894X
pubmed:author	pubmed-author:AllertonCharlotte M NCM, pubmed-author:GbekorEugeneE, pubmed-author:MawGraham NGN, pubmed-author:MillionWilliam AWA
pubmed:issnType	Print
pubmed:day	17
pubmed:volume	13
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1425-8
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:12668004-3',5'-Cyclic-GMP Phosphodiesterases, pubmed-meshheading:12668004-Animals, pubmed-meshheading:12668004-Benzene Derivatives, pubmed-meshheading:12668004-Carbolines, pubmed-meshheading:12668004-Cattle, pubmed-meshheading:12668004-Cyclic Nucleotide Phosphodiesterases, Type 5, pubmed-meshheading:12668004-Dogs, pubmed-meshheading:12668004-Drug Design, pubmed-meshheading:12668004-Humans, pubmed-meshheading:12668004-Inhibitory Concentration 50, pubmed-meshheading:12668004-Isoenzymes, pubmed-meshheading:12668004-Phosphodiesterase Inhibitors, pubmed-meshheading:12668004-Phosphoric Diester Hydrolases, pubmed-meshheading:12668004-Pyrrolidines, pubmed-meshheading:12668004-Recombinant Proteins, pubmed-meshheading:12668004-Spodoptera, pubmed-meshheading:12668004-Structure-Activity Relationship
pubmed:year	2003
pubmed:articleTitle	Design, synthesis and biological activity of beta-carboline-based type-5 phosphodiesterase inhibitors.
pubmed:affiliation	Department of Discovery Chemistry, Pfizer Global Research and Development, Sandwich Laboratories (IPC351), Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK. graham_maw@sandwich.pfizer.com
pubmed:publicationType	Journal Article