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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-3-31
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pubmed:abstractText |
Striatal dysfunction is thought to underlie many dystonias. We used [(123)I]iodobenzovesamicol single-photon emission computed tomography imaging to determine the density of cholinergic terminals in the striatum and other brain regions in 13 subjects with idiopathic cervical dystonia. Striatal [(131)I]iodobenzovesamicol binding was reduced. These results support a role for striatal dysfunction in idiopathic dystonias and suggest diminished striatal cholinergic interneuron density in cervical dystonia.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0364-5134
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
528-32
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12666122-Adult,
pubmed-meshheading:12666122-Aged,
pubmed-meshheading:12666122-Carrier Proteins,
pubmed-meshheading:12666122-Cholinergic Fibers,
pubmed-meshheading:12666122-Corpus Striatum,
pubmed-meshheading:12666122-Female,
pubmed-meshheading:12666122-Humans,
pubmed-meshheading:12666122-Iodine Radioisotopes,
pubmed-meshheading:12666122-Male,
pubmed-meshheading:12666122-Membrane Transport Proteins,
pubmed-meshheading:12666122-Middle Aged,
pubmed-meshheading:12666122-Piperidines,
pubmed-meshheading:12666122-Tetrahydronaphthalenes,
pubmed-meshheading:12666122-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:12666122-Torticollis,
pubmed-meshheading:12666122-Vesicular Acetylcholine Transport Proteins,
pubmed-meshheading:12666122-Vesicular Transport Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Diminished striatal [123I]iodobenzovesamicol binding in idiopathic cervical dystonia.
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pubmed:affiliation |
Geriatrics Research, Education Clinical Center, Ann Arbor VAMC and Department of Neurology, University of Michigan 41809-0585, USA. ralbin@umich.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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