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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-4-29
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pubmed:abstractText |
Defects in the gene encoding Toll-like receptor 4 (Tlr4) result in impaired responses to lipopolysaccharide (LPS), rendering mice sensitive to infections by Gram-negative bacteria. C3H/HeJ mice have a codominant allele with a mutation in Tlr4, which results in an intermediate response to LPS in F1 mice from crosses of responder and C3H/HeJ mice. Here we show that this intermediate response to LPS is due to monoallelic expression of Tlr4. Allele usage is maintained during clonal expansion, a situation that resembles allelic exclusion. In contrast, Tlr4 is deleted on the recessive C57BL/10ScCr allele and all cells from F1 mice from crosses of responder and C57BL/10ScCr mice express TLR4 protein. Thus, Tlr4 is an autosomal gene whose expression is regulated similarly to that of genes on the X chromosome.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1529-2908
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
464-70
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pubmed:dateRevised |
2007-11-8
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pubmed:meshHeading |
pubmed-meshheading:12665857-Alleles,
pubmed-meshheading:12665857-Animals,
pubmed-meshheading:12665857-B-Lymphocytes,
pubmed-meshheading:12665857-Base Sequence,
pubmed-meshheading:12665857-Cell Differentiation,
pubmed-meshheading:12665857-Crosses, Genetic,
pubmed-meshheading:12665857-DNA,
pubmed-meshheading:12665857-Drosophila Proteins,
pubmed-meshheading:12665857-Gene Expression Regulation, Developmental,
pubmed-meshheading:12665857-Gram-Negative Bacterial Infections,
pubmed-meshheading:12665857-Granulocytes,
pubmed-meshheading:12665857-Lipopolysaccharides,
pubmed-meshheading:12665857-Lymphocyte Activation,
pubmed-meshheading:12665857-Membrane Glycoproteins,
pubmed-meshheading:12665857-Mice,
pubmed-meshheading:12665857-Mice, Inbred C3H,
pubmed-meshheading:12665857-Mice, Inbred C57BL,
pubmed-meshheading:12665857-Receptors, Cell Surface,
pubmed-meshheading:12665857-Species Specificity,
pubmed-meshheading:12665857-Toll-Like Receptor 4,
pubmed-meshheading:12665857-Toll-Like Receptors
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pubmed:year |
2003
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pubmed:articleTitle |
Monoallelic expression of the murine gene encoding Toll-like receptor 4.
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pubmed:affiliation |
Unité du Développement des Lymphocytes, CNRS URA 1961, Institut Pasteur, 25 Rue du Docteur Roux, 75015 Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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