Linked Life Data

12665798

Source:http://linkedlifedata.com/resource/pubmed/id/12665798

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-4-25
pubmed:abstractText
It is commonly assumed that odorants are detected by the main olfactory epithelium (MOE) and pheromones are sensed through the vomeronasal organ (VNO). The complete loss of MOE-mediated olfaction in type-3 adenylyl cyclase knockout mice (AC3-/-) allowed us to examine chemosensory functions of the VNO in the absence of signaling through the MOE. Here we report that AC3-/- mice are able to detect certain volatile odorants via the VNO. These same odorants elicited electro-olfactogram transients in the VNO and MOE of wild-type mice, but only VNO responses in AC3-/- mice. This indicates that some odorants are detected through an AC3-independent pathway in the VNO.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1097-6256
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
519-25
pubmed:dateRevised
2009-9-4
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Vomeronasal organ detects odorants in absence of signaling through main olfactory epithelium.
pubmed:affiliation
Molecular and Cellular Biology Program and Department of Pharmacology, University of Washington, Box 357750, 1959 NE Pacific St., Seattle, Washington 98195, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.