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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1976-7-6
|
| pubmed:abstractText |
CSF and serum was obtained from 216 patients with neurological or psychoneurotic symptoms and the concentrations of albumin and IgG were immunologically determined. The IgG/albumin index, calculated as the quotient of the CSF/serum ratios of IgG and albumin was compared with electrophoresis on agar gel. In "normal" cases, the IgG/albumin index was between 0.26-0.66. Pathological electrophoresis, i.e. with two or more IgG bands in the gamma globulin region was found in 85 per cent of the MS patients; in 29 per cent of the patients with a possible demyelinating disease; in 41 per cent of patients with CNS infection; and in 4 per cent of patients with other neurological disorders; whereas an increased IgG/albumin index ( greater than 0.66) was found in 88 per cent of the MS patients; in 43 per cent of the patients with a possible demyelinating disease; in 50 per cent of the patients with CNS infection; in 11 per cent of patients with immunological disorders; and in 18 per cent of patients with other neurological diseases. The increase of the IgG/albumin index was sometimes moderate (0.67-0.90), except in patients with MS, syphilis and other CNS infections, where a pathological electrophoresis combined with an IgG/albumin index above 1.0 was found to be a valuable support for the clinical diagnosis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0001-6314
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
53
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
308-22
|
| pubmed:dateRevised |
2006-8-16
|
| pubmed:meshHeading |
pubmed-meshheading:1266574-Adolescent,
pubmed-meshheading:1266574-Adult,
pubmed-meshheading:1266574-Aged,
pubmed-meshheading:1266574-Albumins,
pubmed-meshheading:1266574-Blood-Brain Barrier,
pubmed-meshheading:1266574-Cerebrospinal Fluid Proteins,
pubmed-meshheading:1266574-Female,
pubmed-meshheading:1266574-Humans,
pubmed-meshheading:1266574-Immune System Diseases,
pubmed-meshheading:1266574-Immunoglobulin G,
pubmed-meshheading:1266574-Infection,
pubmed-meshheading:1266574-Male,
pubmed-meshheading:1266574-Middle Aged,
pubmed-meshheading:1266574-Nervous System Diseases,
pubmed-meshheading:1266574-Serum Albumin
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
A comparison between agar gel electrophoresis and CSF serum quotients of IgG and albumin in neurological disease.
|
| pubmed:publicationType |
Journal Article
|