Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2003-3-31
pubmed:abstractText
The SWI/SNF family of chromatin-remodeling complexes has been discovered in many species and has been shown to regulate gene expression by assisting transcriptional machinery to gain access to their sites in chromatin. Several complexes of this family have been reported for humans. In this study, two additional complexes are described that belong to the same SWI/SNF family. These new complexes contain as many as eight subunits identical to those found in other SWI/SNF complexes, and they possess a similar ATP-dependent nucleosome disruption activity. But unlike known SWI/SNFs, the new complexes are low in abundance and contain an extra subunit conserved between human and yeast SWI/SNF complexes. This subunit, ENL, is a homolog of the yeast SWI/SNF subunit, ANC1/TFG3. Moreover, ENL is a fusion partner for the gene product of MLL that is a common target for chromosomal translocations in human acute leukemia. The resultant MLL-ENL fusion protein associates and cooperates with SWI/SNF complexes to activate transcription of the promoter of HoxA7, a downstream target essential for oncogenic activity of MLL-ENL. Our data suggest that human SWI/SNF complexes show considerable heterogeneity, and one or more may be involved in the etiology of leukemia by cooperating with MLL fusion proteins.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-10078207, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-10399912, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-10466730, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-10516753, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-10638745, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-10688638, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-10813389, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11069025, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11073988, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11078522, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11085541, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11163203, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11238380, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11250140, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11263494, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11532604, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11607819, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11681416, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11734557, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11756182, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11780067, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11790558, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-11988099, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-12368262, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-1346755, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-1423624, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-1901413, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-7477409, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-8047169, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-8080983, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-8223438, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-8232556, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-8414510, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-8506309, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-8662543, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-8668146, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-8804307, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-8895581, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-9129043, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-9435219, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-948749, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-9671307, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-9674423, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-9674424, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-9724757, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-9759497, http://linkedlifedata.com/resource/pubmed/commentcorrection/12665591-9845365
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/ARID1A protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Chromatin, http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/HOXA7 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/MLL protein, human, http://linkedlifedata.com/resource/pubmed/chemical/MLLT1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances, http://linkedlifedata.com/resource/pubmed/chemical/Myeloid-Lymphoid Leukemia Protein, http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Protein Subunits, http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2942-52
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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