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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2003-3-28
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pubmed:abstractText |
Several picornaviruses shut down host cellular protein synthesis by proteolytic cleavage of the eukaryotic initiation factor (eIF) 4GI and eIF4GII isoforms. Viral RNA translation is maintained by a cap-independent mechanism. Here, we identify the human rhinovirus 2 2A(pro) cleavage site in eIF4GII in vitro as PLLNV(699)*GSR; this sequence lies seven amino acids C-terminal to the cleavage site previously identified in eIF4GI (LSTR681*GPP).
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-10074204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-1017010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-10867028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-10913184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-10950867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-11073214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-11172724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-11445534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-11483526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-11565745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-12052860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-1332040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-1429670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-174102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-174106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-2304461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-2839690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-2839775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-291969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-7651417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-7665619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-7745693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-8338854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-8396129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-8970966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-9200613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-9302999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-9418880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-9736694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663812-9857202
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/EIF4G1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/EIF4G2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Eukaryotic Initiation Factor-4G,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Initiation Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/picornain 2A, Picornavirus
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5026-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12663812-Amino Acid Sequence,
pubmed-meshheading:12663812-Cysteine Endopeptidases,
pubmed-meshheading:12663812-Eukaryotic Initiation Factor-4G,
pubmed-meshheading:12663812-HeLa Cells,
pubmed-meshheading:12663812-Humans,
pubmed-meshheading:12663812-Molecular Sequence Data,
pubmed-meshheading:12663812-Peptide Fragments,
pubmed-meshheading:12663812-Peptide Initiation Factors,
pubmed-meshheading:12663812-Rhinovirus,
pubmed-meshheading:12663812-Sequence Alignment,
pubmed-meshheading:12663812-Viral Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different.
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pubmed:affiliation |
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada H3G 1Y6.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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