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pubmed-article:12663809pubmed:abstractTextThe absolute and relative abundance of major histocompatibility complex class I-presented viral epitopes is important in the induction and maintenance of antiviral cytotoxic-T-lymphocyte (CTL) responses. We demonstrate that the supra-abundant HLA-A*0201-restricted peptide KLWESPQEI of the measles virus nonstructural C protein induces strong gamma interferon CD8(+)-T-cell responses in children with acute measles. However, longitudinal analysis indicates that these responses are only short-lived. Thus, some viral epitopes that can be immunodominant during primary infection may fail to establish memory CTL responses.lld:pubmed
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pubmed-article:12663809pubmed:articleTitleVigorous but short-term gamma interferon T-cell responses against a dominant HLA-A*02-restricted measles virus epitope in patients with measles.lld:pubmed
pubmed-article:12663809pubmed:affiliationMedical Research Council Laboratories, Banjul, The Gambia. ajaye@mrc.gmlld:pubmed
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