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rdf:type |
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lifeskim:mentions |
umls-concept:C0003316,
umls-concept:C0019728,
umls-concept:C0021745,
umls-concept:C0025007,
umls-concept:C0025011,
umls-concept:C0030705,
umls-concept:C0871261,
umls-concept:C1333899,
umls-concept:C1527180,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
8
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pubmed:dateCreated |
2003-3-28
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pubmed:abstractText |
The absolute and relative abundance of major histocompatibility complex class I-presented viral epitopes is important in the induction and maintenance of antiviral cytotoxic-T-lymphocyte (CTL) responses. We demonstrate that the supra-abundant HLA-A*0201-restricted peptide KLWESPQEI of the measles virus nonstructural C protein induces strong gamma interferon CD8(+)-T-cell responses in children with acute measles. However, longitudinal analysis indicates that these responses are only short-lived. Thus, some viral epitopes that can be immunodominant during primary infection may fail to establish memory CTL responses.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663809-10760807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663809-10769074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663809-11899069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663809-12479394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663809-3403997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663809-7500030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663809-7529283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663809-7638857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663809-8026983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663809-8469287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663809-8838344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663809-9419365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663809-9593013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663809-9806631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663809-9835622
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5014-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12663809-Epitopes, T-Lymphocyte,
pubmed-meshheading:12663809-HLA-A Antigens,
pubmed-meshheading:12663809-Humans,
pubmed-meshheading:12663809-Immunodominant Epitopes,
pubmed-meshheading:12663809-Interferon-gamma,
pubmed-meshheading:12663809-Measles,
pubmed-meshheading:12663809-Measles virus,
pubmed-meshheading:12663809-Peptides,
pubmed-meshheading:12663809-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:12663809-Viral Nonstructural Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Vigorous but short-term gamma interferon T-cell responses against a dominant HLA-A*02-restricted measles virus epitope in patients with measles.
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pubmed:affiliation |
Medical Research Council Laboratories, Banjul, The Gambia. ajaye@mrc.gm
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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