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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0026447,
umls-concept:C0039194,
umls-concept:C0042196,
umls-concept:C0079189,
umls-concept:C0185117,
umls-concept:C0277785,
umls-concept:C0522424,
umls-concept:C1332714,
umls-concept:C2348867,
umls-concept:C2911684
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pubmed:issue |
8
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pubmed:dateCreated |
2003-3-28
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pubmed:abstractText |
Human immunodeficiency virus type 1 infection results in a dysfunction of CD4(+) T lymphocytes. The intracellular events contributing to that CD4(+) T-lymphocyte dysfunction remain incompletely elucidated, and it is unclear whether aspects of that dysfunction can be prevented. The present studies were pursued in a rhesus monkey model of AIDS to explore these issues. Loss of the capacity of peripheral blood CD4(+) T lymphocytes to express cytokines was first detected in simian immunodeficiency virus-infected monkeys during the peak of viral replication during primary infection and persisted thereafter. Moreover, infected monkeys with progressive disease had peripheral blood CD4(+) T lymphocytes that expressed significantly less cytokine than infected monkeys that had undetectable viral loads and intact CD4(+) T-lymphocyte counts. Importantly, CD4(+) T lymphocytes from vaccinated monkeys that effectively controlled the replication of a highly pathogenic immunodeficiency virus isolate following a challenge had a preserved functional capacity. These observations suggest that an intact cytokine expression capacity of CD4(+) T lymphocytes is associated with stable clinical status and that effective vaccines can mitigate against CD4(+) T-lymphocyte dysfunction following an AIDS virus infection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-10395840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-10564559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-10570196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-10737796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-11029005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-11039923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-11069239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-11544282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-11797011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-11986671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-2176140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-2184033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-2413136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-2974045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-6422299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-7903129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-7905652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-7907233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-7911534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-7966595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-8551565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-8786327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-8794335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-9119996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-9367954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-9710601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12663776-9858506
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4695-702
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12663776-AIDS Vaccines,
pubmed-meshheading:12663776-Animals,
pubmed-meshheading:12663776-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12663776-Cytokines,
pubmed-meshheading:12663776-HIV Infections,
pubmed-meshheading:12663776-HIV-1,
pubmed-meshheading:12663776-Humans,
pubmed-meshheading:12663776-Macaca mulatta,
pubmed-meshheading:12663776-SAIDS Vaccines,
pubmed-meshheading:12663776-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:12663776-Simian immunodeficiency virus,
pubmed-meshheading:12663776-Vaccination,
pubmed-meshheading:12663776-Vaccines, DNA
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pubmed:year |
2003
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pubmed:articleTitle |
Global dysfunction of CD4 T-lymphocyte cytokine expression in simian-human immunodeficiency virus/SIV-infected monkeys is prevented by vaccination.
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pubmed:affiliation |
Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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