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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-3-28
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pubmed:abstractText |
Five new alkaloids, dictyodendrins A-E (1-5), were isolated from the Japanese marine sponge Dictyodendrilla verongiformis as telomerase inhibitors. Their structures were elucidated by spectroscopic and chemical methods. Dictyodendrins are tyramine-based pyrrolocarbazole derivatives containing three or four p-hydroxybenzene groups. They inhibited telomerase completely at a concentration of 50 microg/mL.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-3263
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2765-70
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12662050-Alkaloids,
pubmed-meshheading:12662050-Animals,
pubmed-meshheading:12662050-Carbazoles,
pubmed-meshheading:12662050-Enzyme Inhibitors,
pubmed-meshheading:12662050-Hydrolysis,
pubmed-meshheading:12662050-Japan,
pubmed-meshheading:12662050-Molecular Structure,
pubmed-meshheading:12662050-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:12662050-Porifera,
pubmed-meshheading:12662050-Pyrroles,
pubmed-meshheading:12662050-Stereoisomerism,
pubmed-meshheading:12662050-Telomerase,
pubmed-meshheading:12662050-Tyramine
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pubmed:year |
2003
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pubmed:articleTitle |
Dictyodendrins A-E, the first telomerase-inhibitory marine natural products from the sponge Dictyodendrilla verongiformis.
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pubmed:affiliation |
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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