|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2003-3-27
|
|
pubmed:abstractText |
It has been proposed that the structural and numerical chromosome abnormalities recorded in breast cancer could be the result of telomere dysfunction and that telomerase is activated de novo to provide a survival mechanism curtailing further chromosomal aberrations. However, recent in vivo and in vitro data show that the ectopic expression of telomerase promotes tumorigenesis via a telomere length-independent mechanism. In this study, the relation between telomerase expression and the extent of chromosomal aberrations was investigated in 62 primary breast carcinomas. Telomerase activity was measured using a polymerase chain reaction-based telomeric repeat amplification protocol assay and 92% of the tumors were found to express telomerase with a relative activity ranging from 0 to 3839.6. Genetic alterations were determined by G-banding and comparative genomic hybridization analysis and 97% of the tumors exhibited chromosomal aberrations ranging from 0 to 44 (average: 10.98). In the overall series, the relationship between telomerase activity levels and genetic changes could be best described by a quadratic model, whereas in tumors with below-average genetic alteration numbers, a significant positive association was recorded between the two variables (coefficient=0.374, P=.017). The relationship between telomerase activity levels and the extent of genetic alteration may reflect the complex effect of telomerase activation upon tumor progression in breast carcinomas.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-10456708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-10493971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-10688864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-10949306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-11089982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-11494114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-11509177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-11746982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-11807988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-11896565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-12032846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-12034875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-12193655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-12370834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-1384657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-222468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-3907856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-7479015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-7544491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-7605428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-7630414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-8134364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-8444465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-8537972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-8811183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-9258662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-9472105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-9637678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12659690-9815730
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1522-8002
|
|
pubmed:author |
pubmed-author:AgnantisNiki JNJ,
pubmed-author:AndersenJohan AJA,
pubmed-author:DimitriadisEuthimiosE,
pubmed-author:HeimSverreS,
pubmed-author:IoannidisPanayiotisP,
pubmed-author:PandisNikosN,
pubmed-author:PapadopoulouAnnaA,
pubmed-author:TeixeiraManuel RMR,
pubmed-author:TrangasTheoniT,
pubmed-author:TsarouhaHaroulaH,
pubmed-author:UWW
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
5
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
170-8
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:12659690-Adult,
pubmed-meshheading:12659690-Age Factors,
pubmed-meshheading:12659690-Aged,
pubmed-meshheading:12659690-Aged, 80 and over,
pubmed-meshheading:12659690-Breast Neoplasms,
pubmed-meshheading:12659690-Carcinoma,
pubmed-meshheading:12659690-Cell Line, Tumor,
pubmed-meshheading:12659690-Chromosome Aberrations,
pubmed-meshheading:12659690-Chromosome Banding,
pubmed-meshheading:12659690-Cytogenetics,
pubmed-meshheading:12659690-Disease Progression,
pubmed-meshheading:12659690-Female,
pubmed-meshheading:12659690-Humans,
pubmed-meshheading:12659690-Middle Aged,
pubmed-meshheading:12659690-Telomerase,
pubmed-meshheading:12659690-Time Factors
|
|
pubmed:articleTitle |
Telomerase activity and genetic alterations in primary breast carcinomas.
|
|
pubmed:affiliation |
Department of Genetics, Saint Savas Hospital, Athens, Greece.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
