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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-3-26
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pubmed:abstractText |
A series of MT-II related cyclic peptides, based on potent but non-selective hMC4R agonist (Penta-c[Asp-His(6)-DPhe(7)-Arg(8)-Trp(9)-Lys]-NH(2)) was prepared in which His(6) residue was systematically substituted. Two of the most interesting peptides identified in this study are Penta-c[Asp-5-ClAtc-DPhe-Arg-Trp-Lys]-NH(2) and Penta-c[Asp-5-ClAtc-DPhe-Cit-Trp-Lys]-NH(2) which are potent hMC4R agonists and are either inactive or weak partial agonists (not tested for their antagonist activities) in hMC1R, hMC3R and hMC5R agonist assays.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:ChenLiL,
pubmed-author:CheungAdrian Wai-HingAW,
pubmed-author:ChuXin-JieXJ,
pubmed-author:DanhoWaleedW,
pubmed-author:FrancoLuciaL,
pubmed-author:KurylkoGrazynaG,
pubmed-author:QiLidaL,
pubmed-author:RowanKarenK,
pubmed-author:SwistokJosephJ,
pubmed-author:YagaloffKeithK,
pubmed-author:YeonMitchM
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1307-11
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:12657270-Amino Acid Substitution,
pubmed-meshheading:12657270-Cell Survival,
pubmed-meshheading:12657270-Histidine,
pubmed-meshheading:12657270-Humans,
pubmed-meshheading:12657270-Magnetic Resonance Spectroscopy,
pubmed-meshheading:12657270-Peptides, Cyclic,
pubmed-meshheading:12657270-Receptor, Melanocortin, Type 4,
pubmed-meshheading:12657270-Receptors, Corticotropin,
pubmed-meshheading:12657270-Receptors, Melanocortin,
pubmed-meshheading:12657270-Structure-Activity Relationship,
pubmed-meshheading:12657270-Tumor Cells, Cultured
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pubmed:year |
2003
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pubmed:articleTitle |
Structure-activity relationship of cyclic peptide penta-c[Asp-His(6)-DPhe(7)-Arg(8)-Trp(9)-Lys]-NH(2) at the human melanocortin-1 and -4 receptors: His(6) substitution.
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pubmed:affiliation |
Roche Research Center, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. adrian.cheung@roche.com
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pubmed:publicationType |
Journal Article
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