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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-3-26
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pubmed:abstractText |
Phthalocyanine-based photosensitizers, coupled via a 17alpha-ethynyl group to estradiol using Pd(II) as a catalyst, were synthesized and evaluated for their estrogen receptor binding affinity and in vitro photocytotoxicity. The highest receptor binding affinities (RBA=8-13) were observed with lipophilic conjugates coupled via a relative long spacer group while the sulfonated analogues showed little binding affinities (RBA <2). The highest photocytotoxicity was observed with the sulfonated conjugates, the nature of the spacer group did not have a pronounced effect.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1287-90
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12657265-Catalysis,
pubmed-meshheading:12657265-Cell Survival,
pubmed-meshheading:12657265-Estradiol,
pubmed-meshheading:12657265-Humans,
pubmed-meshheading:12657265-Indicators and Reagents,
pubmed-meshheading:12657265-Indoles,
pubmed-meshheading:12657265-Light,
pubmed-meshheading:12657265-Magnetic Resonance Spectroscopy,
pubmed-meshheading:12657265-Palladium,
pubmed-meshheading:12657265-Photosensitizing Agents,
pubmed-meshheading:12657265-Receptors, Estrogen,
pubmed-meshheading:12657265-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:12657265-Tumor Cells, Cultured
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pubmed:year |
2003
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pubmed:articleTitle |
Synthesis and biological activities of phthalocyanine-estradiol conjugates.
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pubmed:affiliation |
Department of Chemistry, A.M.U. Aligarh (U.P.) India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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