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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-3-26
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pubmed:abstractText |
The development of a series of novel indole-based inhibitors of 5'-inosine monophosphate dehydrogenase (IMPDH) is described. Various hydrogen bond acceptors at C-3 of the indole were explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are outlined.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BallentineShelley KSK,
pubmed-author:BarrishJoel CJC,
pubmed-author:CheneyDanielD,
pubmed-author:DharT G MuraliTG,
pubmed-author:FleenerCatherine ACA,
pubmed-author:HollenbaughDiane LDL,
pubmed-author:IwanowiczEdwin JEJ,
pubmed-author:RouleauKatherine AKA,
pubmed-author:ShenZhongqiZ,
pubmed-author:TownsendRobertR,
pubmed-author:WattersonScott HSH
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1273-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:12657262-Cell Division,
pubmed-meshheading:12657262-Enzyme Inhibitors,
pubmed-meshheading:12657262-Glucuronides,
pubmed-meshheading:12657262-Humans,
pubmed-meshheading:12657262-Hydrogen Bonding,
pubmed-meshheading:12657262-IMP Dehydrogenase,
pubmed-meshheading:12657262-Immune System,
pubmed-meshheading:12657262-Indoles,
pubmed-meshheading:12657262-Isoenzymes,
pubmed-meshheading:12657262-Mitogens,
pubmed-meshheading:12657262-Quinolones,
pubmed-meshheading:12657262-Stereoisomerism,
pubmed-meshheading:12657262-Structure-Activity Relationship
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pubmed:year |
2003
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pubmed:articleTitle |
Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3.
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pubmed:affiliation |
Bristol-Myers Squibb PRI, Princeton, NJ 08543-4000, USA. scott.watterson@bms.com
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pubmed:publicationType |
Journal Article
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