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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2003-3-26
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pubmed:abstractText |
Alteration of glutamate and gamma-aminobutyrate system have been reported to be associated with neurodegenerative disorders and have been postulated to be involved in aluminum-induced neurotoxicity as well. Aluminum, an well known and commonly exposed neurotoxin, was found to alter glutamate and gamma-aminobutyrate levels as well as activities of associated enzymes with regional specificity. Protein malnutrition also reported to alter glutamate level and some of its metabolic enzymes. Thus the region-wise study of levels of brain glutamate and gamma-aminobutyrate system in protein adequacy and inadequacy may be worthwhile to understand the mechanism of aluminum-induced neurotoxicity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-10048751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-10806405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-11130287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-11226739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-11346489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-11696403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-12197946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-1982955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-2888068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-34672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-3952185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-3996513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-6052988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-6159461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-845676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-8817578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-9437657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-9513917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-9530999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-9531000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12657166-963531
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1471-2202
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12657166-4-Aminobutyrate Transaminase,
pubmed-meshheading:12657166-Aluminum,
pubmed-meshheading:12657166-Aluminum Compounds,
pubmed-meshheading:12657166-Animals,
pubmed-meshheading:12657166-Body Weight,
pubmed-meshheading:12657166-Brain,
pubmed-meshheading:12657166-Brain Chemistry,
pubmed-meshheading:12657166-Cerebellum,
pubmed-meshheading:12657166-Chlorides,
pubmed-meshheading:12657166-Diet, Protein-Restricted,
pubmed-meshheading:12657166-Dietary Proteins,
pubmed-meshheading:12657166-Drug Administration Schedule,
pubmed-meshheading:12657166-Eating,
pubmed-meshheading:12657166-Glutamate Decarboxylase,
pubmed-meshheading:12657166-Glutamic Acid,
pubmed-meshheading:12657166-Hippocampus,
pubmed-meshheading:12657166-Injections, Intraperitoneal,
pubmed-meshheading:12657166-Male,
pubmed-meshheading:12657166-Rats,
pubmed-meshheading:12657166-Rats, Wistar,
pubmed-meshheading:12657166-Telencephalon,
pubmed-meshheading:12657166-Thalamus,
pubmed-meshheading:12657166-gamma-Aminobutyric Acid
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pubmed:year |
2003
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pubmed:articleTitle |
Dietary protein restriction causes modification in aluminum-induced alteration in glutamate and GABA system of rat brain.
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pubmed:affiliation |
Department of Physiology, Sikkim Manipal Institute of Medical Sciences, 5th Mile, Tadong, Gangtok 737102, Sikkim, India. nprasunpriya@hotmail.com
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pubmed:publicationType |
Journal Article
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