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rdf:type |
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lifeskim:mentions |
umls-concept:C0001721,
umls-concept:C0018067,
umls-concept:C0018284,
umls-concept:C0019269,
umls-concept:C0037083,
umls-concept:C0136134,
umls-concept:C0162610,
umls-concept:C1515926,
umls-concept:C1622501,
umls-concept:C1710082,
umls-concept:C2242140
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pubmed:issue |
1
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pubmed:dateCreated |
2003-3-25
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pubmed:abstractText |
The unc-52 gene of Claenorhabditis elegans encodes a homologue of the basement membrane heparan sulfate proteoglycan perlecan. Viable alleles reduce the abundance of UNC-52 in late larval stages and increase the frequency of distal tip cell (DTC) migration defects caused by mutations disrupting the UNC-6/netrin guidance system. These unc-52 alleles do not cause circumferential DTC migration defects in an otherwise wild-type genetic background. The effects of unc-52 mutations on DTC migrations are distinct from effects on myofilament organization and can be partially suppressed by mutations in several genes encoding growth factor-like molecules, including EGL-17/FGF, UNC-129/TGF-beta, DBL-1/TGF-beta, and EGL-20/WNT. We propose that UNC-52 serves dual roles in C. elegans larval development in the maintenance of muscle structure and the regulation of growth factor-like signaling pathways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CLR-1 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/EGL-15 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor-Like Protein Tyrosine...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fibroblast Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/UNC-5 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/UNC-6 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/unc-52 protein, C elegans
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0012-1606
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
256
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-86
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12654300-Animals,
pubmed-meshheading:12654300-Animals, Genetically Modified,
pubmed-meshheading:12654300-Caenorhabditis elegans,
pubmed-meshheading:12654300-Caenorhabditis elegans Proteins,
pubmed-meshheading:12654300-Cell Movement,
pubmed-meshheading:12654300-Disorders of Sex Development,
pubmed-meshheading:12654300-Female,
pubmed-meshheading:12654300-Genes, Helminth,
pubmed-meshheading:12654300-Gonads,
pubmed-meshheading:12654300-Growth Substances,
pubmed-meshheading:12654300-Helminth Proteins,
pubmed-meshheading:12654300-Larva,
pubmed-meshheading:12654300-Male,
pubmed-meshheading:12654300-Membrane Proteins,
pubmed-meshheading:12654300-Muscles,
pubmed-meshheading:12654300-Mutation,
pubmed-meshheading:12654300-Nerve Tissue Proteins,
pubmed-meshheading:12654300-Phenotype,
pubmed-meshheading:12654300-Protein Tyrosine Phosphatases,
pubmed-meshheading:12654300-Proteoglycans,
pubmed-meshheading:12654300-Receptor-Like Protein Tyrosine Phosphatases,
pubmed-meshheading:12654300-Receptors, Cell Surface,
pubmed-meshheading:12654300-Receptors, Fibroblast Growth Factor,
pubmed-meshheading:12654300-Signal Transduction
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pubmed:year |
2003
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pubmed:articleTitle |
UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling.
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pubmed:affiliation |
Department of Molecular and Medical Genetics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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