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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-3-25
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pubmed:abstractText |
Transcription factor Nrf2 regulates the expression of a set of detoxifying and anti-oxidant enzyme genes. Several lines of evidence suggest that electrophiles and reactive oxygen species liberate Nrf2 from its cytoplasmic repressor Keap1 and provoke the accumulation of Nrf2 in the nucleus. To elucidate the molecular mechanisms as to how Nrf2 is activated by inducers, we examined the cytoplasmic-nuclear shuttling and turnover of Nrf2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Keap1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/NF-E2-Related Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Nfe2l2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1356-9597
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
379-91
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12653965-Active Transport, Cell Nucleus,
pubmed-meshheading:12653965-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:12653965-Animals,
pubmed-meshheading:12653965-Carrier Proteins,
pubmed-meshheading:12653965-Cell Nucleus,
pubmed-meshheading:12653965-Cells, Cultured,
pubmed-meshheading:12653965-Cysteine Endopeptidases,
pubmed-meshheading:12653965-Cytoplasm,
pubmed-meshheading:12653965-Cytoskeletal Proteins,
pubmed-meshheading:12653965-DNA-Binding Proteins,
pubmed-meshheading:12653965-Gene Expression Regulation,
pubmed-meshheading:12653965-Immunoblotting,
pubmed-meshheading:12653965-Intestinal Mucosa,
pubmed-meshheading:12653965-Liver,
pubmed-meshheading:12653965-Macrophages,
pubmed-meshheading:12653965-Mice,
pubmed-meshheading:12653965-Multienzyme Complexes,
pubmed-meshheading:12653965-NF-E2-Related Factor 2,
pubmed-meshheading:12653965-Proteasome Endopeptidase Complex,
pubmed-meshheading:12653965-Protein Binding,
pubmed-meshheading:12653965-RNA, Messenger,
pubmed-meshheading:12653965-Trans-Activators
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pubmed:year |
2003
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pubmed:articleTitle |
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles.
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pubmed:affiliation |
Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8577, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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