Linked Life Data

12653685

Source:http://linkedlifedata.com/resource/pubmed/id/12653685

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-3-25
pubmed:abstractText
The clinical presentation of pre-eclampsia suggests that microvascular dysfunction may play a role in the maternal manifestations of the disease. Isovolumetric venous pressure ( P V(i)) is an index of microvascular function, reflecting local plasma colloid osmotic (oncotic) pressure, and is abnormal in clinical conditions with microvascular dysfunction. We hypothesized that, in pre-eclampsia, post-capillary margination of neutrophils would increase post-capillary resistance, and therefore P V(i). A small cumulative step strain-gauge plethysmography protocol was used to compare P V(i) in 18 women with pre-eclampsia, 16 normal pregnant women and 17 non-pregnant controls. Circulating levels of vascular cell-adhesion molecule-1 (VCAM-1), intercellular cell-adhesion molecule-1 (ICAM-1) and E-selectin, and neutrophil elastase, were measured to assess endothelial and neutrophil activation respectively. P V(i) was significantly greater in the pre-eclampsia group, relative to the normal pregnant and non-pregnant controls ( P <0.001, ANOVA, for both comparisons). P V(i) was significantly lower during normal pregnancy compared with the non-pregnant controls ( P =0.001). Plasma levels of neutrophil elastase, VCAM-1, ICAM-1 and E-selectin ( P =0.001) were significantly greater in the pre-eclamptics than the controls. Significant positive correlations were observed between P V(i) and neutrophil elastase ( r =0.71, P =0.001), VCAM-1 ( r =0.52, P =0.03), ICAM-1 ( r =0.67, P =0.002), E-selectin ( r =0.69, P =0.001), uric acid levels ( r =0.54, P =0.02) and haematocrit ( r =0.64, P =0.004) in pre-eclampsia. The relationship with the platelet count was negative ( r =-0.65, P =0.003). No significant correlations were observed between P V(i) and maternal age, gestational age, total protein, albumin, diastolic blood pressures, age, body mass index and infant birth mass in the normal pregnant and non-pregnant controls. These data suggest that microvascular dysfunction occurs in pre-eclampsia, and that it is related to alterations in endothelial cell and neutrophil activation.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0143-5221
pubmed:author
pubmed:issnType
Print
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
405-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12653685-Adult, pubmed-meshheading:12653685-Case-Control Studies, pubmed-meshheading:12653685-E-Selectin, pubmed-meshheading:12653685-Endothelium, Vascular, pubmed-meshheading:12653685-Female, pubmed-meshheading:12653685-Hematocrit, pubmed-meshheading:12653685-Humans, pubmed-meshheading:12653685-Intercellular Adhesion Molecule-1, pubmed-meshheading:12653685-Leukocyte Elastase, pubmed-meshheading:12653685-Microcirculation, pubmed-meshheading:12653685-Neutrophil Activation, pubmed-meshheading:12653685-Placental Circulation, pubmed-meshheading:12653685-Plethysmography, pubmed-meshheading:12653685-Pre-Eclampsia, pubmed-meshheading:12653685-Pregnancy, pubmed-meshheading:12653685-Regression Analysis, pubmed-meshheading:12653685-Uric Acid, pubmed-meshheading:12653685-Vascular Cell Adhesion Molecule-1, pubmed-meshheading:12653685-Venous Pressure
pubmed:year
2003
pubmed:articleTitle
Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study.
pubmed:affiliation
Department of Maternal and Fetal Medicine, Imperial College School of Medicine at Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, U.K. n.anim@ic.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't