Source:http://linkedlifedata.com/resource/pubmed/id/12652301
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2003-3-31
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| pubmed:abstractText |
To address the quality and completeness of single-nucleotide polymorphism (SNP) databases, we resequenced 173 kb (spanning 17 loci) in 150 chromosomes of west African and European ancestry. Over 88% of SNPs in the public (TSC and BAC overlap) and Celera databases were confirmed in independent resequencing. Approximately 45% of all human heterozygosity is attributable to SNPs already available from the two databases, and of SNPs with minor-allele frequencies >10%, more than half are represented.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1061-4036
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
457-8
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:12652301-Alleles,
pubmed-meshheading:12652301-Chromosome Mapping,
pubmed-meshheading:12652301-Databases as Topic,
pubmed-meshheading:12652301-Genetic Variation,
pubmed-meshheading:12652301-Genome, Human,
pubmed-meshheading:12652301-Haplotypes,
pubmed-meshheading:12652301-Heterozygote,
pubmed-meshheading:12652301-Humans,
pubmed-meshheading:12652301-Polymorphism, Single Nucleotide,
pubmed-meshheading:12652301-Sequence Analysis, DNA
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| pubmed:year |
2003
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| pubmed:articleTitle |
Quality and completeness of SNP databases.
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| pubmed:affiliation |
Program in Medical and Population Genetics, Whitehead Institute / MIT Center for Genome Research, One Kendall Square, Cambridge, Massachusetts 02139, USA. reich@genome.wi.mit.edu
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| pubmed:publicationType |
Journal Article
|