Linked Life Data

12652187

Source:http://linkedlifedata.com/resource/pubmed/id/12652187

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-3-24
pubmed:abstractText
Projections of duration of life for humans based on mathematical models have led some researchers to claim that there is no lower limit to death rates or upper limit to life expectancy, and that a life expectancy of 100 will be achieved in the 21st century. To assess the biological plausibility of these claims, we examined temporal aspects of biological phenomena in three mammalian species. Our examination revealed that: (1) physiological declines associated with reproduction consistently occur at ages that are less than one-third of the median age at death, (2) physiological parameters associated with aging in humans lose eighty percent of their functional capacity by age 80, and (3) young versus old individuals can be distinguished by the pathologies detected at death. The biological evidence suggests that organisms operate under warranty periods that limit the duration of life of individuals and the life expectancy of populations. We use these findings to discuss the issue of limits to the duration of life and the validity of mathematical models used to forecast human longevity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1389-5729
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
31-45
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Biological evidence for limits to the duration of life.
pubmed:affiliation
Center on Aging, National Opinion Research Center, University of Chicago, 1155 E. 60th Street, Chicago, IL 60637, USA. bruce@src.uchicago.edu
pubmed:publicationType
Journal Article