Linked Life Data

12651647

Source:http://linkedlifedata.com/resource/pubmed/id/12651647

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-3-24
pubmed:abstractText
We designed this randomized, double-blinded, placebo-controlled study to compare the analgesic effect of the cyclooxygenase-2 inhibitors rofecoxib and celecoxib with acetaminophen when administered before outpatient otolaryngologic surgery in 240 healthy subjects. Patients were assigned to one of four study groups: Group 1, control (vitamin C 500 mg); Group 2, acetaminophen 2 g; Group 3, celecoxib 200 mg; or Group 4, rofecoxib 50 mg. The first oral dose of the study medication was administered 15-45 min before surgery, and a second dose of the same medication was given on the morning after surgery. Recovery times, side effects, pain scores, and the use of rescue analgesics were recorded. Follow-up evaluations were performed at 24 and 48 h after surgery to assess postdischarge pain, analgesic requirements, nausea, and patient satisfaction with their postoperative pain management and quality of recovery. The need for rescue analgesia and peak pain scores were used as the primary end points for estimating efficacy, and the costs to achieve complete satisfaction with analgesia were used for the cost-efficacy comparisons. Premedication with oral rofecoxib (50 mg) or celecoxib (200 mg) was more effective than placebo in reducing postoperative pain scores and analgesic requirements in the postoperative care unit and after discharge. The analgesic efficacy of oral acetaminophen (2 g) was limited to the postdischarge period. Patient satisfaction with pain management was improved in all three treatment groups compared with placebo but was higher with celecoxib and rofecoxib compared with acetaminophen. Rofecoxib was also more effective than celecoxib in reducing pain and improving patient satisfaction after otolaryngologic surgery. Rofecoxib achieved complete satisfaction with pain control in one additional patient, who would not have otherwise been satisfied, at lower incremental costs to the institution compared with celecoxib. We conclude that rofecoxib 50 mg orally is more cost-effective for reducing postoperative pain and improving patient satisfaction with their postoperative pain management than celecoxib (200 mg) or acetaminophen (2 g) in the ambulatory setting. IMPLICATIONS: Oral premedication with rofecoxib (50 mg) was more effective than celecoxib (200 mg) and acetaminophen (2 g) in reducing postoperative pain and in improving the quality of recovery and patient satisfaction with pain management after outpatient otolaryngologic surgery with only a small increase in cost of care.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0003-2999
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
987-94, table of contents
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12651647-Acetaminophen, pubmed-meshheading:12651647-Adolescent, pubmed-meshheading:12651647-Adult, pubmed-meshheading:12651647-Aged, pubmed-meshheading:12651647-Ambulatory Surgical Procedures, pubmed-meshheading:12651647-Analgesics, Opioid, pubmed-meshheading:12651647-Cyclooxygenase Inhibitors, pubmed-meshheading:12651647-Double-Blind Method, pubmed-meshheading:12651647-Female, pubmed-meshheading:12651647-Humans, pubmed-meshheading:12651647-Lactones, pubmed-meshheading:12651647-Male, pubmed-meshheading:12651647-Middle Aged, pubmed-meshheading:12651647-Otorhinolaryngologic Surgical Procedures, pubmed-meshheading:12651647-Pain, Postoperative, pubmed-meshheading:12651647-Pain Measurement, pubmed-meshheading:12651647-Patient Satisfaction, pubmed-meshheading:12651647-Postoperative Nausea and Vomiting, pubmed-meshheading:12651647-Pyrazoles, pubmed-meshheading:12651647-Sulfonamides, pubmed-meshheading:12651647-Sulfones
pubmed:year
2003
pubmed:articleTitle
Costs and effectiveness of rofecoxib, celecoxib, and acetaminophen for preventing pain after ambulatory otolaryngologic surgery.
pubmed:affiliation
Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, 34th Street & Civic Center Boulevard, Philadelphia, PA 19104, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't