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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2003-3-24
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pubmed:abstractText |
We have identified nine cyclophilins encoded in the genome of the fission yeast Schizosaccharomyces pombe (Sp). Cyclophilin 3 is an orthologue of hUSA-CyP, which is associated with Prp4/Prp3 in the [U4/U6.U5] snRNP complex and Prp18, both of which are components of the pre-mRNA splicing machinery. PPIase assays have shown SpCyp3 and hUSA-CyP to have comparable activity and substrate specificity, but SpCyp3 has a reduced sensitivity to CsA correlating with a difference in the catalytic site. Prp3, Prp4 and Prp18 proteins exist in S. pombe and nuclear localisation of SpCyp3 has been shown, indicating conservation of function between hUSA-CyP and SpCyp3.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1570-0232
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
786
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-91
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12651004-Amino Acid Sequence,
pubmed-meshheading:12651004-Base Sequence,
pubmed-meshheading:12651004-Cyclophilin A,
pubmed-meshheading:12651004-Cyclophilins,
pubmed-meshheading:12651004-DNA, Fungal,
pubmed-meshheading:12651004-DNA Primers,
pubmed-meshheading:12651004-Humans,
pubmed-meshheading:12651004-Models, Molecular,
pubmed-meshheading:12651004-Molecular Sequence Data,
pubmed-meshheading:12651004-Schizosaccharomyces,
pubmed-meshheading:12651004-Schizosaccharomyces pombe Proteins,
pubmed-meshheading:12651004-Sequence Homology, Amino Acid
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pubmed:year |
2003
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pubmed:articleTitle |
Identification and characterisation of Schizosaccharomyces pombe cyclophilin 3, a cyclosporin A insensitive orthologue of human USA-CyP.
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pubmed:affiliation |
The School of Biological Sciences, University of Sussex, Falmer, East Sussex, BN1 9QG, Brighton, UK. t.j.pemberton@sussex.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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