|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0027651,
umls-concept:C0030705,
umls-concept:C0042672,
umls-concept:C0201734,
umls-concept:C0205179,
umls-concept:C0205208,
umls-concept:C0205390,
umls-concept:C0574032,
umls-concept:C0585333,
umls-concept:C0672663,
umls-concept:C1521801
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2003-3-21
|
|
pubmed:abstractText |
Vinflunine is a novel vinca alkaloid obtained by semi-synthesis using super-acidic chemistry to selectively introduce two fluorine atoms at the 20' position of vinorelbine. In human tumour xenografts, vinflunine showed definite antitumour activity in seven out of 11 tumours tested compared with three out of 11 for vinorelbine.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0923-7534
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
630-7
|
|
pubmed:dateRevised |
2004-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:12649112-Adult,
pubmed-meshheading:12649112-Aged,
pubmed-meshheading:12649112-Antineoplastic Agents,
pubmed-meshheading:12649112-Constipation,
pubmed-meshheading:12649112-Drug Administration Schedule,
pubmed-meshheading:12649112-Female,
pubmed-meshheading:12649112-Humans,
pubmed-meshheading:12649112-Infusions, Intravenous,
pubmed-meshheading:12649112-Male,
pubmed-meshheading:12649112-Maximum Tolerated Dose,
pubmed-meshheading:12649112-Middle Aged,
pubmed-meshheading:12649112-Mouth Mucosa,
pubmed-meshheading:12649112-Neoplasms,
pubmed-meshheading:12649112-Neutropenia,
pubmed-meshheading:12649112-Stomatitis,
pubmed-meshheading:12649112-Vinblastine
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Phase I and pharmacokinetic study of the new vinca alkaloid vinflunine administered as a 10-min infusion every 3 weeks in patients with advanced solid tumours.
|
|
pubmed:affiliation |
Centre René Gauducheau, Nantes-Saint-Herblain, France. j-bennouna@nantes.fnclcc.fr
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Clinical Trial, Phase I
|
