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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-3-21
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pubmed:abstractText |
AIM: The available evidence supporting the importance of cyclooxygenase-2 (COX-2) in the regulation of renal haemodynamics and excretory function is summarized. Cyclooxygenase-2-derived metabolites play a very important role in regulating renal haemodynamics when sodium intake is low whereas it plays a minor role in the control of cortical blood flow when sodium intake is normal or elevated. The importance of COX-2 in the regulation of renal haemodynamics seems to be dependent on the endogenous production of other vasoactive products such as nitric oxide (NO) or noradrenaline. The activation of COX-2 in response to a decrease in NO may represent a mechanism aimed at defending the renal vasculature in the face of a decrease in NO levels. CONCLUSION: Contrary to the important role of COX-2 in the long-term regulation of renal haemodynamics, the metabolites derived from COX-2 seem to be only involved in the acute regulation of renal excretory function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0001-6772
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
429-35
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12648160-Absorption,
pubmed-meshheading:12648160-Animals,
pubmed-meshheading:12648160-Cyclooxygenase 2,
pubmed-meshheading:12648160-Dogs,
pubmed-meshheading:12648160-Glomerular Filtration Rate,
pubmed-meshheading:12648160-Hemodynamics,
pubmed-meshheading:12648160-Hydroxyeicosatetraenoic Acids,
pubmed-meshheading:12648160-Isoenzymes,
pubmed-meshheading:12648160-Kidney,
pubmed-meshheading:12648160-Kidney Cortex,
pubmed-meshheading:12648160-Nitric Oxide,
pubmed-meshheading:12648160-Norepinephrine,
pubmed-meshheading:12648160-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12648160-Renal Circulation,
pubmed-meshheading:12648160-Renin,
pubmed-meshheading:12648160-Sodium,
pubmed-meshheading:12648160-Urination,
pubmed-meshheading:12648160-Vasoconstriction
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pubmed:year |
2003
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pubmed:articleTitle |
Role of cyclooxygenase-2 in the control of renal haemodynamics and excretory function.
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pubmed:affiliation |
Department of Physiology, School of Medicine, University of Murcia, Murcia, Spain.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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