| pubmed-article:12646922 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12646922 | lifeskim:mentions | umls-concept:C0221908 | lld:lifeskim |
| pubmed-article:12646922 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:12646922 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:12646922 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:12646922 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:12646922 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:12646922 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:12646922 | lifeskim:mentions | umls-concept:C2700462 | lld:lifeskim |
| pubmed-article:12646922 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:12646922 | pubmed:issue | 6929 | lld:pubmed |
| pubmed-article:12646922 | pubmed:dateCreated | 2003-3-20 | lld:pubmed |
| pubmed-article:12646922 | pubmed:abstractText | The morphogenesis of organs as diverse as lungs, teeth and hair follicles is initiated by a downgrowth from a layer of epithelial stem cells. During follicular morphogenesis, stem cells form this bud structure by changing their polarity and cell-cell contacts. Here we show that this process is achieved through simultaneous receipt of two external signals: a Wnt protein to stabilize beta-catenin, and a bone morphogenetic protein (BMP) inhibitor to produce Lef1. Beta-catenin then binds to, and activates, Lef1 transcription complexes that appear to act uncharacteristically by downregulating the gene encoding E-cadherin, an important component of polarity and intercellular adhesion. When either signal is missing, functional Lef1 complexes are not made, and E-cadherin downregulation and follicle morphogenesis are impaired. In Drosophila, E-cadherin can influence the plane of cell division and cytoskeletal dynamics. Consistent with this notion, we show that forced elevation of E-cadherin levels block invagination and follicle production. Our findings reveal an intricate molecular programme that links two extracellular signalling pathways to the formation of a nuclear transcription factor that acts on target genes to remodel cellular junctions and permit follicle formation. | lld:pubmed |
| pubmed-article:12646922 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12646922 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12646922 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12646922 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12646922 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:12646922 | pubmed:author | pubmed-author:FuchsElaineE | lld:pubmed |
| pubmed-article:12646922 | pubmed:author | pubmed-author:JamoraColinC | lld:pubmed |
| pubmed-article:12646922 | pubmed:author | pubmed-author:DasGuptaRaman... | lld:pubmed |
| pubmed-article:12646922 | pubmed:author | pubmed-author:KocieniewskiP... | lld:pubmed |
| pubmed-article:12646922 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12646922 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:12646922 | pubmed:volume | 422 | lld:pubmed |
| pubmed-article:12646922 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12646922 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12646922 | pubmed:pagination | 317-22 | lld:pubmed |
| pubmed-article:12646922 | pubmed:dateRevised | 2011-2-16 | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:meshHeading | pubmed-meshheading:12646922... | lld:pubmed |
| pubmed-article:12646922 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12646922 | pubmed:articleTitle | Links between signal transduction, transcription and adhesion in epithelial bud development. | lld:pubmed |
