Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6929
pubmed:dateCreated
2003-3-20
pubmed:abstractText
The morphogenesis of organs as diverse as lungs, teeth and hair follicles is initiated by a downgrowth from a layer of epithelial stem cells. During follicular morphogenesis, stem cells form this bud structure by changing their polarity and cell-cell contacts. Here we show that this process is achieved through simultaneous receipt of two external signals: a Wnt protein to stabilize beta-catenin, and a bone morphogenetic protein (BMP) inhibitor to produce Lef1. Beta-catenin then binds to, and activates, Lef1 transcription complexes that appear to act uncharacteristically by downregulating the gene encoding E-cadherin, an important component of polarity and intercellular adhesion. When either signal is missing, functional Lef1 complexes are not made, and E-cadherin downregulation and follicle morphogenesis are impaired. In Drosophila, E-cadherin can influence the plane of cell division and cytoskeletal dynamics. Consistent with this notion, we show that forced elevation of E-cadherin levels block invagination and follicle production. Our findings reveal an intricate molecular programme that links two extracellular signalling pathways to the formation of a nuclear transcription factor that acts on target genes to remodel cellular junctions and permit follicle formation.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-10655586, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-10655587, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-11239416, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-11371349, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-11445543, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-11520664, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-11934263, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-11956233, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-12049767, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-12086873, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-12408870, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-12646907, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-1566372, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-8608945, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-8647435, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-8892228, http://linkedlifedata.com/resource/pubmed/commentcorrection/12646922-9988217
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cadherins, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Lef1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Lymphoid Enhancer-Binding Factor 1, http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances, http://linkedlifedata.com/resource/pubmed/chemical/Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins, http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin, http://linkedlifedata.com/resource/pubmed/chemical/noggin protein
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
422
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
317-22
pubmed:dateRevised
2011-2-16
pubmed:meshHeading
pubmed-meshheading:12646922-Adherens Junctions, pubmed-meshheading:12646922-Animals, pubmed-meshheading:12646922-Bone Morphogenetic Proteins, pubmed-meshheading:12646922-Cadherins, pubmed-meshheading:12646922-Carrier Proteins, pubmed-meshheading:12646922-Cell Adhesion, pubmed-meshheading:12646922-Cytoskeletal Proteins, pubmed-meshheading:12646922-DNA-Binding Proteins, pubmed-meshheading:12646922-Down-Regulation, pubmed-meshheading:12646922-Epithelial Cells, pubmed-meshheading:12646922-Gene Deletion, pubmed-meshheading:12646922-Gene Expression Regulation, Developmental, pubmed-meshheading:12646922-Hair Follicle, pubmed-meshheading:12646922-In Situ Hybridization, pubmed-meshheading:12646922-Lymphoid Enhancer-Binding Factor 1, pubmed-meshheading:12646922-Macromolecular Substances, pubmed-meshheading:12646922-Mice, pubmed-meshheading:12646922-Mice, Knockout, pubmed-meshheading:12646922-Mice, Transgenic, pubmed-meshheading:12646922-Morphogenesis, pubmed-meshheading:12646922-Proteins, pubmed-meshheading:12646922-Proto-Oncogene Proteins, pubmed-meshheading:12646922-RNA, Messenger, pubmed-meshheading:12646922-Signal Transduction, pubmed-meshheading:12646922-Stem Cells, pubmed-meshheading:12646922-Trans-Activators, pubmed-meshheading:12646922-Transcription, Genetic, pubmed-meshheading:12646922-Transcription Factors, pubmed-meshheading:12646922-Wnt Proteins, pubmed-meshheading:12646922-Zebrafish Proteins, pubmed-meshheading:12646922-beta Catenin
pubmed:year
2003
pubmed:articleTitle
Links between signal transduction, transcription and adhesion in epithelial bud development.
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