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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-3-20
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pubmed:abstractText |
Activation-induced cell death (AICD) of T cells is one of the major mechanisms of peripheral tolerance. The regulation of AICD by IL-4 is poorly understood. In this study, we report that AICD in IL-4-deficient T cells is significantly reduced compared with that in wild-type T cells. This impaired AICD correlates with the failure to induce degradation of cellular FLIP. IL-4-mediated enhancement of AICD and cellular FLIP degradation requires a Janus kinase/STAT-6 signaling pathway. Unexpectedly, these effects of IL-4 could be blocked by a neutralizing anti-IL-2 Ab, and addition of rIL-2 could completely restore the defective AICD in IL-4-deficient T cells. Furthermore, IL-4 regulates the T cell thresholds for IL-2 signaling during AICD. These data suggest that IL-4 promotes AICD via an IL-2-dependent mechanism.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/CASP8 and FADD-Like Apoptosis...,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cflar protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Fasl protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/STAT6 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
170
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3495-503
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12646610-Adjuvants, Immunologic,
pubmed-meshheading:12646610-Animals,
pubmed-meshheading:12646610-Antigens, CD95,
pubmed-meshheading:12646610-Apoptosis,
pubmed-meshheading:12646610-CASP8 and FADD-Like Apoptosis Regulating Protein,
pubmed-meshheading:12646610-Carrier Proteins,
pubmed-meshheading:12646610-Cells, Cultured,
pubmed-meshheading:12646610-Drug Synergism,
pubmed-meshheading:12646610-Fas Ligand Protein,
pubmed-meshheading:12646610-Interleukin-2,
pubmed-meshheading:12646610-Interleukin-4,
pubmed-meshheading:12646610-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12646610-Ligands,
pubmed-meshheading:12646610-Lymphocyte Activation,
pubmed-meshheading:12646610-Membrane Glycoproteins,
pubmed-meshheading:12646610-Mice,
pubmed-meshheading:12646610-Mice, Inbred BALB C,
pubmed-meshheading:12646610-Mice, Inbred C57BL,
pubmed-meshheading:12646610-Mice, Knockout,
pubmed-meshheading:12646610-Mice, Transgenic,
pubmed-meshheading:12646610-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:12646610-Receptors, Antigen, T-Cell,
pubmed-meshheading:12646610-STAT6 Transcription Factor,
pubmed-meshheading:12646610-Signal Transduction,
pubmed-meshheading:12646610-T-Lymphocyte Subsets,
pubmed-meshheading:12646610-Trans-Activators,
pubmed-meshheading:12646610-Up-Regulation
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pubmed:year |
2003
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pubmed:articleTitle |
IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanism.
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pubmed:affiliation |
Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University at Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA. jzhang1@rush.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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