Linked Life Data

12646403

Source:http://linkedlifedata.com/resource/pubmed/id/12646403

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-3-20
pubmed:abstractText
Hyperthyroidism was induced by daily subcutaneous injections of L-thyroxine (T(4), 0.5 mg/kg/day) for 3 days, 1 week, or 2 weeks to study whether there is a fluctuation in adrenoceptor- and muscarinic receptor-mediated blood pressure responses at a hyperthyroid stage. T(4) treatment for 3 days or 1 week significantly suppressed the pressor response induced by norepinephrine (NE). The depressor responses induced by isoprenaline or acetylcholine (ACh) were increased by T(4) treatment for only 3 days. The pressor response induced by N(G)-nitro-L-arginine (L-NA) was increased by T(4) treatment for only 3 days. Results suggest that adrenoceptor- and muscarinic receptor-mediated blood pressure responses fluctuate in hyperthyroidism caused by T(4) in rats, that the basal nitric oxide (NO) production and/or release are increased in hyperthyroid rats at an early stage of the disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1537-1891
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
A fluctuation in adrenocepter- and muscarinic receptor-mediated blood pressure responses in acute hyperthyroid rats.
pubmed:affiliation
Department of Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Japan. hhonda@ps.toyaku.ac.jp
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't