Source:http://linkedlifedata.com/resource/pubmed/id/12645937
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2003-3-20
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| pubmed:abstractText |
This study has enabled us to identify the influence of the chemokine, macrophage inflammatory protein-1alpha (MIP-1alpha), on leukocyte behavior at the blood-retina barrier in vivo and its link with the inflammatory process and disease pathogenesis. MIP-1alpha has not previously been thought to be effective under conditions of physiological shear flow. However, short-term anti-MIP-1alpha treatment inhibited leukocyte slowing and accumulation and subsequent extravasation of leukocytes at the blood-retina barrier in animals with experimental autoimmune uveoretinitis. This was effective predominantly in the post-capillary venules which have been shown to be the main site of passage of leukocytes across the blood-retina barrier. Long-term anti-MIP-1alpha treatment also prevented decreased leukocyte velocity and reduced disease severity as measured clinically, histologically and in terms of blood-retina barrier breakdown.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0014-2980
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
402-10
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12645937-Animals,
pubmed-meshheading:12645937-Antibodies, Monoclonal,
pubmed-meshheading:12645937-Autoimmune Diseases,
pubmed-meshheading:12645937-Blood-Retinal Barrier,
pubmed-meshheading:12645937-Cell Adhesion,
pubmed-meshheading:12645937-Chemokine CCL3,
pubmed-meshheading:12645937-Chemokine CCL4,
pubmed-meshheading:12645937-Chemotaxis, Leukocyte,
pubmed-meshheading:12645937-Disease Progression,
pubmed-meshheading:12645937-Endothelium, Vascular,
pubmed-meshheading:12645937-Female,
pubmed-meshheading:12645937-Hemorheology,
pubmed-meshheading:12645937-Lasers,
pubmed-meshheading:12645937-Leukocyte Rolling,
pubmed-meshheading:12645937-Leukocytes,
pubmed-meshheading:12645937-Macrophage Inflammatory Proteins,
pubmed-meshheading:12645937-Mice,
pubmed-meshheading:12645937-Microscopy, Confocal,
pubmed-meshheading:12645937-Ophthalmoscopes,
pubmed-meshheading:12645937-Ophthalmoscopy,
pubmed-meshheading:12645937-Retinitis,
pubmed-meshheading:12645937-Uveitis,
pubmed-meshheading:12645937-Venules
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Effect of anti-macrophage inflammatory protein-1alpha on leukocyte trafficking and disease progression in experimental autoimmune uveoretinitis.
|
| pubmed:affiliation |
Department of Ophthalmology, University of Aberdeen Medical School, Foresterhill, Aberdeen, GB. i.j.crane@abdn.ac.uk
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|