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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-3-19
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pubmed:abstractText |
The human immunodeficiency virus (HIV-1) (transactivator of transcription (Tat)) protein is a pleiotropic factor that induces a broad range of biological effects in numerous cell types. At the HIV promoter, Tat is a powerful transactivator of gene expression, which acts by both inducing chromatin remodeling and by recruiting elongation-competent transcriptional complexes onto the viral LTR. Besides these transcriptional activities, Tat is released outside the cells and interacts with different cell membrane-associated receptors. Finally, extracellular Tat can be internalized by cells through an active endocytosis process. Here we discuss some of the molecular mechanisms involved in intracellular and extracellular Tat function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Chromatin,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tat,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Positive Transcriptional...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/RNA Polymerase II,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Virus,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/tat Gene Products, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0378-1097
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
220
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-65
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12644228-Acetylation,
pubmed-meshheading:12644228-Acetyltransferases,
pubmed-meshheading:12644228-Bacteriophage lambda,
pubmed-meshheading:12644228-Chromatin,
pubmed-meshheading:12644228-Endocytosis,
pubmed-meshheading:12644228-Extracellular Space,
pubmed-meshheading:12644228-Gene Expression Regulation, Viral,
pubmed-meshheading:12644228-Gene Products, tat,
pubmed-meshheading:12644228-Genes, tat,
pubmed-meshheading:12644228-HIV Long Terminal Repeat,
pubmed-meshheading:12644228-HIV-1,
pubmed-meshheading:12644228-Histone Acetyltransferases,
pubmed-meshheading:12644228-Histones,
pubmed-meshheading:12644228-Humans,
pubmed-meshheading:12644228-Intracellular Fluid,
pubmed-meshheading:12644228-Models, Biological,
pubmed-meshheading:12644228-Positive Transcriptional Elongation Factor B,
pubmed-meshheading:12644228-Promoter Regions, Genetic,
pubmed-meshheading:12644228-Protein Processing, Post-Translational,
pubmed-meshheading:12644228-Protein-Serine-Threonine Kinases,
pubmed-meshheading:12644228-RNA, Messenger,
pubmed-meshheading:12644228-RNA, Viral,
pubmed-meshheading:12644228-RNA Polymerase II,
pubmed-meshheading:12644228-Receptors, Virus,
pubmed-meshheading:12644228-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:12644228-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:12644228-Transcriptional Activation,
pubmed-meshheading:12644228-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2003
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pubmed:articleTitle |
HIV Tat, its TARgets and the control of viral gene expression.
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pubmed:affiliation |
Molecular Oncology Laboratory, National Cancer Research Institute, c/o Centro di Biotecnologie Avanzante, Largo Rosanna Benzi 10, 16132 Genova, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Review,
Research Support, Non-U.S. Gov't
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