|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2003-3-19
|
|
pubmed:abstractText |
To examine whether hydroxamic acids are inducers of fetal hemoglobin expression, we tested the effects on gamma gene expression of butyric and propionic hydroxamic acids and of two other hydroxamic acids (SBHA and SAHA), which are potent inhibitors of histone deacetylase (HDAC). We also investigated whether there is a correlation between HDAC inhibitory activity of the compounds and their ability to induce gamma-globin gene expression.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0301-472X
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2003 International Society for Experimental Hematology
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
31
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
197-203
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:12644016-Animals,
pubmed-meshheading:12644016-Blood Cells,
pubmed-meshheading:12644016-Dose-Response Relationship, Drug,
pubmed-meshheading:12644016-Enzyme Inhibitors,
pubmed-meshheading:12644016-Erythroid Precursor Cells,
pubmed-meshheading:12644016-Fatty Acids, Volatile,
pubmed-meshheading:12644016-Fetal Hemoglobin,
pubmed-meshheading:12644016-Gene Expression Regulation,
pubmed-meshheading:12644016-Globins,
pubmed-meshheading:12644016-Histone Deacetylase Inhibitors,
pubmed-meshheading:12644016-Humans,
pubmed-meshheading:12644016-Hydroxamic Acids,
pubmed-meshheading:12644016-Mice,
pubmed-meshheading:12644016-Promoter Regions, Genetic,
pubmed-meshheading:12644016-Tumor Cells, Cultured
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Hydroxamide derivatives of short-chain fatty acids are potent inducers of human fetal globin gene expression.
|
|
pubmed:affiliation |
Division of Medical Genetics, University of Washington, Seattle, Wash 98195, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
